SCH 221510 (CAS 322473-89-2)
別名:
3-Endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
アプリケーション：
SCH 221510 is A potent and selective nociceptin opiod receptor (KOR-3) agonist.
CAS 番号:
322473-89-2
Molecular Weight:
397.55
Molecular Formula:
C28H31NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SCH 221510 is a selective and potent nociceptin opioid receptor (NOP) also known as KOR-3 receptor agonist, (EC50 values are 12, 693, 683 and 8071 nM, and Ki values are 0.3, 65, 131 and 2854 nM at NOP, μ-, κ- and δ-opioid receptors respectively). SCH 221510 also exhibits anxiolytic-like activity.
参考文献
1. Varty, G.B. et al. 2008. J. Pharmacol. Exp. Ther. 326(2): 672-682. PMID: 18492950
2. Lambert, D.G. 2008. Nat Rev Drug Discov. 7(8): 694-710. PMID: 18670432
3. Yang, S.W. et al. 2009. Bioorg. Med. Chem. Lett. 19(9): 2482-2486. PMID: 19332374
Physical State
:
Solid
Solubility
:
Soluble in DMSO (100 mM), and ethanol (10 mM).
保存方法
:
Store at room temperature
IC50
:
NOP: EC5050 = 12 nM; κ-opioid receptors: EC5050 = 683 nM; μ-opioid receptors: EC5050 = 693 nM
Ki Data
:
NOP: Ki= 0.3 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID
:
SMILES
:
CC1=CC=CC=C1C(C2=CC=CC=C2C)N3C4CCC3CC(C4)(C5=CC=CC=C5)O
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分析表
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