SCH-202676 hydrobromide CAS: 70375-43-8
MF: C15H13N3S·HBr
MW: 348.3
A modulator that inhibits binding to G protein-coupled receptors.

SCH-202676 hydrobromide (CAS 70375-43-8)

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同義語 N-(2,3-diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene)methanamine hydrobromide
アプリケーション: A modulator that inhibits binding to G protein-coupled receptors
CAS 番号: 70375-43-8
Purity: ≥99%
Molecular Weight: 348.3
Molecular Formula: C15H13N3S·HBr
* Refer to Certificate of Analysis for lot specific data (including water content).
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SCH-202676 hydrobromide is a G protein-coupled receptor allosteric modulator that has been shown to inhibit agonist and antagonist binding to a wide range of G protein-coupled receptors that are structurally unrelated. SCH-202676 hydrobromide has displayed divergent effects on purine receptors. It is reported to inhibit radioligand binding to human Adenosine A1-R, A2A-R, and A3-R and thus affects dissociation kinetics.


参考文献

1. Fawzi, A.B., et al. 2001. Mol. Pharmacol. 59: 30-37. PMID: 11125021
2. Lanzafame, A., et al. 2004. J. Pharmacol. Exp. Ther. 308: 830-837. PMID: 14617684
3. Gao, Z.G., et al. 2004. Life Sci. 74: 3173-3180. PMID: 15081581
4. Lewandowicz, A.M., et al. 2006. Br. J. Pharmacol. 147: 422-429. PMID: 16402041

Physical State :
Solid
Solubility :
Soluble in DMSO (40 mg/ml), water, and ethanol.
保存方法 :
Store at room temperature
Melting Point :
240.0-240.8° C (lit.)
Boiling Point :
423.8° C at 760 mmHg
IC50 :
large T antigen: IC50 = 29.42 µM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
11957689
MDL Number :
MFCD06671539
SMILES :
CN=C1N=C(N(S1)C2=CC=CC=C2)C3=CC=CC=C3.Br

Download SDS (MSDS)

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