(RS)-PPG (CAS 120667-15-4)

身体の状態 :

Solid

溶解度 :

Soluble in 1eq. NaOH (100 mM), and DMSO (2 mg/ml).

保存方法 :

Store at 4° C

融点 :

300° C

沸騰点 :

515.54° C at 760 mmHg (Predicted)

密度 :

1.62 g/cm³ (Predicted)

屈折率 :

n²⁰_D 1.64 (Predicted)

IC50 :

Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation: EC₅₀50 = 0.21 µM (rat nonneuronal cells); Inhibition of forskolin stimulated cAMP accumulation: EC₅₀50 = 3.2 µM (CHO cells expressing hmGluR4a); Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation: EC₅₀50 = 4.7 µM (rat nonneuronal cells); Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells: EC₅₀50 = 4.7 µM; Metabotropic glutamate receptor 4 agonist activity to influence forskolin stimulated c-AMP formation: EC₅₀50 = 5.2 µM (rat nonneuronal cells)

Ki データ :

mGLuR-8a: K_i= 0.21 µM (human); mGluR-6: K_i= 4.7 µM (human); mGluR-4: K_i= 5.2 µM (human)

pK値 :

pK_a: 1.62 (Predicted), pK_b: 10.2 (Predicted)

WGKドイツ :

3

PubChem CID :

MDL番号 :

MFCD02262122

SMILES :

C1=CC(=CC=C1C(C(=O)O)N)P(=O)(O)O