Rpn10D Antibody (B-4): sc-514990

Rpn10D Antibody (B-4) is a mouse monoclonal IgM antibody that detects Rpn10D protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Rpn10D antibody (B-4) is available as the non-conjugated form. Rpn10D plays a crucial role in the ubiquitin-proteasome system, which is essential for maintaining cellular homeostasis by regulating protein degradation. Rpn10D (B-4) antibody recognizes and binds multiubiquitinated substrates, facilitating their delivery to the 26S proteasome for degradation. This process is vital for various cellular functions, including the removal of damaged or misfolded proteins, thus preventing the accumulation of potentially toxic proteins that could disrupt cellular function. Rpn10D and related isoforms, generated through alternative splicing of the PSMD4 gene, exhibit specific expression patterns during embryonic development, suggesting specialized roles in developmental processes. Anti-Rpn10D antibody (B-4) interaction with other proteins in the ubiquitin-proteasome pathway underscores its importance in cellular regulation and development, making this antibody a valuable tool for researchers studying protein degradation mechanisms and their implications in health and disease.

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Rpn10D Antibody (B-4) References:

1. The 26S proteasome: a molecular machine designed for controlled proteolysis.  |  Voges, D., et al. 1999. Annu Rev Biochem. 68: 1015-68. PMID: 10872471
2. Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes.  |  Kawahara, H., et al. 2000. EMBO J. 19: 4144-53. PMID: 10921894
3. Purification and characterization of the antisecretory factor: a protein in the central nervous system and in the gut which inhibits intestinal hypersecretion induced by cholera toxin.  |  Lönnroth, I. and Lange, S. 1986. Biochim Biophys Acta. 883: 138-44. PMID: 3524692
4. Molecular cloning and expression of a pituitary gland protein modulating intestinal fluid secretion.  |  Johansson, E., et al. 1995. J Biol Chem. 270: 20615-20. PMID: 7657640
5. Structure and functions of the 20S and 26S proteasomes.  |  Coux, O., et al. 1996. Annu Rev Biochem. 65: 801-47. PMID: 8811196

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rpn10D Antibody (B-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Rpn10D Antibody (B-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rpn10D Antibody (B-4) Specifications

Alternate Product Name: Rpn10D

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 301-320

Epitope Target: Rpb10D

Epitope Species: mouse

Product Reactivity/Detection: Rpn10D

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Rpn10D Antibody (B-4): X: TransCruz Reagent

The preferred PSMD4 antibody is PSMD4 Antibody (F-6): sc-398033.