RHC-80267 CAS: 83654-05-1
MF: C20H34N4O4
MW: 394.51
A selective inhibitor of DAG lipase and PKC activator.

RHC-80267 (CAS 83654-05-1)

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別名: 1,6-bis(Cyclohexyloximinocarbonylamino)hexane; 1,6-Di(O-(carbamoyl)cyclohexanone oxime)hexane
アプリケーション: RHC-80267 is a selective inhibitor of DAG lipase and PKC activator
CAS 番号: 83654-05-1
Purity: 98%
Molecular Weight: 394.51
Molecular Formula: C20H34N4O4
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* Refer to Certificate of Analysis for lot specific data (including water content).

RHC-80267 is a selective inhibitor of DAGL (DAG lipase) activity in canine platelets and in a variety of mammalian cells. RHC-80267 also inhibits glucose- and carbachol-induced insulin release from intact islets. RHC-80267 has been shown to be an inhibitor of Angiotensin II (sc-363643) and ATP-induced synthesis of 6-keto-prostaglandin F (sc-201238). RHC-80267 is an activator of PKC (protein kinase C).


参考文献

Shinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295. Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207. Konrad, R.J., et al. 1994. Biochemistry 33, 13284. Mason-Garcia, M., et al. 1992. Am. J. Physiol. 262, C1197. Balsinde, J., et al. 1991. J. Biol. Chem. 266, 15638.

Physical State :
Solid
Solubility :
Soluble in DMSO (9 mg/ml), and 100% ethanol (25 mg/ml).
保存方法 :
Store at room temperature
Melting Point :
118-121° C
Density :
1.21 g/cm3
Refractive Index :
n20D 1.57
IC50 :
DAG lipase activity: IC50 = 4 nM (canine platelets); Sn1-specific diacylglycerol lipase alpha: IC50 = 60 nM (human); Sn1-specific diacylglycerol lipase beta: IC50 = 60 nM (human); adipocyte lipolysis: IC50 = 1 µM (rat adipocyte); free fatty acid liberation: IC50 = 4 µM (Canine myocardial lipase)
pK Values :
pKa: 13.81 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00210844
SMILES :
C1CCC(=NOC(=O)NCCCCCCNC(=O)ON=C2CCCCC2)CC1

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