(R)-(-)-Apomorphine hydrochloride CAS: 314-19-2
MF: C17H17NO2 HCl
MW: 303.79
A prototypical dopamine agonist.

(R)-(-)-Apomorphine hydrochloride (CAS 314-19-2)

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アプリケーション: (R)-(−)-Apomorphine hydrochloride is a prototypical dopamine agonist
CAS 番号: 314-19-2
Purity: >95%
Molecular Weight: 303.79
Molecular Formula: C17H17NO2 HCl
補足情報: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
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* Refer to Certificate of Analysis for lot specific data (including water content).

(R)-(-)-Apomorphine hydrochloride is a prototypical dopamine agonist (pKi values are 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4 and D5 receptors respectively). (R)-(-)-Apomorphine hydrochloride, produces biphasic effects on locomotor activity, displays antiparkinsonian, and neuroprotective actions when systemically administered in vivo.


参考文献

1. Liu, X., et al. 1996. Pharmacol. Biochem. Behav. 53: 335-340. PMID: 8808141
2. Grunblatt, E., et al. 1999. Mov. Disord. 14: 612-618. PMID: 10435498
3. Millan, M.J., et al. 2002. J. Pharmacol. Exp. Ther. 303: 791-804. PMID: 12388666

Physical State :
Solid
Solubility :
Soluble in water (50 mM), and DMSO (100 mM). and mixes with alcohol (1:50).
保存方法 :
Store at room temperature
Melting Point :
195° C
Boiling Point :
473.4° C at 760 mmHg (Predicted)
Optical Activity :
α20/D -46°, c = 1.2 in water
IC50 :
Dopamine D2 receptor: IC50 = 87 nM (rat); Dopamine D3 receptor: IC50 = 69.5 nM (rat)
Ki Data :
Dopamine D3 receptor: Ki= 3.7 nM (rat); Dopamine D1 receptor: Ki= 3.7 nM (rat); Dopamine D2 receptor: Ki= 3.7 nM (rat)
pK Values :
pKa: 9.43 (Predicted), pKb: 7.88 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
RTECS :
CE0700000
PubChem CID :
Merck Index :
14: 746
MDL Number :
MFCD00069236
EC Number :
206-243-0
SMILES :
CN1CCC2=CC=CC3=C2[[email protected]]1CC4=C3C(=C(C=C4)O)O.Cl

Download SDS (MSDS)

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