Molecular structure of (R)-(−)-Apomorphine hydrochloride, CAS Number: 314-19-2
(R)-(−)-Apomorphine hydrochloride (CAS 314-19-2)
Application:
(R)-(−)-Apomorphine hydrochloride is a prototypical dopamine agonist
CAS Number:
314-19-2
Purity:
>95%
Molecular Weight:
303.79
Molecular Formula:
C17H17NO2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(R)-(−)-Apomorphine hydrochloride is a compound consisting of apomorphine and hydrochloric acid. It functions as a prototypical dopamine agonist. Being a dopamine agonist, (R)-(−)-Apomorphine hydrochloride binds to dopamine receptors and activates them. In vitro experiments have focused on evaluating the influence of (R)-(−)-Apomorphine hydrochloride on cell signaling pathways, gene expression, and cell morphology.
(R)-(−)-Apomorphine hydrochloride (CAS 314-19-2) References
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- Effects of conantokins on L-3,4-dihydroxyphenylalanine-induced behavior and immediate early gene expression. | Adams, AC., et al. 2000. Eur J Pharmacol. 404: 303-13. PMID: 10996596
- Stability of apomorphine hydrochloride in aqueous sodium bisulphite solutions. | Ng Ying Kin, NM., et al. 2001. Prog Neuropsychopharmacol Biol Psychiatry. 25: 1461-8. PMID: 11513359
- Transdermal permeation of apomorphine through hairless mouse skin from microemulsions. | Peira, E., et al. 2001. Int J Pharm. 226: 47-51. PMID: 11532569
- Pretreatment with a water-based surfactant formulation affects transdermal iontophoretic delivery of R-apomorphine in vitro. | Li, GL., et al. 2003. Pharm Res. 20: 653-9. PMID: 12739775
- The role of dopamine receptors in ventrolateral orbital cortex-evoked antinociception in a rat formalin test model. | Dang, YH., et al. 2011. Eur J Pharmacol. 657: 97-103. PMID: 21316357
- Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors. | Thomas, AG., et al. 2013. Biochem Biophys Res Commun. 438: 243-8. PMID: 23850693
- Intracerebral injection of R-(-)-Apomorphine into the nucleus accumbens decreased carbachol-induced 22-kHz ultrasonic vocalizations in rats. | Silkstone, M. and Brudzynski, SM. 2019. Behav Brain Res. 364: 264-273. PMID: 30690109
- The antagonistic relationship between aversive and appetitive emotional states in rats as studied by pharmacologically-induced ultrasonic vocalization from the nucleus accumbens and lateral septum. | Silkstone, M. and Brudzynski, SM. 2019. Pharmacol Biochem Behav. 181: 77-85. PMID: 31034853
- Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson's disease rat model. | Park, HW., et al. 2020. Sci Rep. 10: 9572. PMID: 32533070
- Vascular effects of apomorphine and related compounds in the perfused rat kidney. | Schmidt, M., et al. 1984. Eur J Pharmacol. 97: 75-85. PMID: 6141949
- Effects of an intrathecal dopamine agonist, apomorphine, on thermal and chemical evoked noxious responses in rats. | Jensen, TS. and Yaksh, TL. 1984. Brain Res. 296: 285-93. PMID: 6322926
- The role of spinal pathways in dopamine mediated alteration in the tail-flick reflex in rats. | Jensen, TS., et al. 1984. Neuropharmacology. 23: 149-53. PMID: 6546973
- Distribution of apomorphine enantiomers in plasma, brain tissue and striatal extracellular fluid. | Sam, E., et al. 1997. Eur J Pharmacol. 329: 9-15. PMID: 9218678
- Naloxone does not alter amphetamine-induced rotational behavior or striatal dopamine levels of nigrally-lesioned rats. | Kimmel, HL., et al. 1998. Brain Res. 789: 171-4. PMID: 9602114
Inhibitor of:
MUP13.Activator of:
D1DR, D2DR, D3DR, D4DR, and D5DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-(−)-Apomorphine hydrochloride, 5 mg | sc-203675A | 5 mg | $84.00 | |||
(R)-(−)-Apomorphine hydrochloride, 50 mg | sc-203675 | 50 mg | $161.00 | |||
(R)-(−)-Apomorphine hydrochloride, 500 mg | sc-203675B | 500 mg | $421.00 |