Quinaprilat CAS: 82768-85-2
MF: C23H26N2O5
MW: 410.46
A metabolite of Quinapril that acts as an ACE inhibitor.

Quinaprilat (CAS 82768-85-2)

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別名: USP Quinapril Related Compound B
アプリケーション: Quinaprilat is a metabolite of Quinapril that acts as an ACE inhibitor
CAS 番号: 82768-85-2
Molecular Weight: 410.46
Molecular Formula: C23H26N2O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
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* Refer to Certificate of Analysis for lot specific data (including water content).

Quinaprilat is the active metabolite of Quinapril and a ACE (angiotensin converting enzyme) inhibitor. This compound prevents the catalyzed conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, and by preventing its formation, vasodilation occurs along with increased capillary blood volume.


参考文献

Maurer, H., et al.: Ther. Drug. Monit., 20, 706 (1998), Yamada, S., et al.: Biol. Pharm. Bull., 26, 872 (2003),

Physical State :
Solid
Solubility :
Soluble in methanol.
保存方法 :
Store at 4° C
Melting Point :
144-146° C
Boiling Point :
~674.5° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Optical Activity :
α20/D +19.5°±3.5°, c = 1 in methanol
IC50 :
ACE: IC50 = 2.8 nM (human)
pK Values :
pKa: 2.19 (Predicted), pKb: 7.67 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
107994
MDL Number :
MFCD00865778
SMILES :
C[[email protected]@H](C(=O)N1CC2=CC=CC=C2C[[email protected]]1C(=O)O)N[[email protected]@H](CCC3=CC=CC=C3)C(=O)O

Download SDS (MSDS)

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