Quinaprilat (CAS 82768-85-2)
別名:
USP Quinapril Related Compound B
アプリケーション：
Quinaprilat is a metabolite of Quinapril that acts as an ACE inhibitor
CAS 番号:
82768-85-2
Molecular Weight:
410.46
Molecular Formula:
C23H26N2O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
Quinaprilat is the active metabolite of Quinapril and a ACE (angiotensin converting enzyme) inhibitor. This compound prevents the catalyzed conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, and by preventing its formation, vasodilation occurs along with increased capillary blood volume.
参考文献
Maurer, H., et al.: Ther. Drug. Monit., 20, 706 (1998), Yamada, S., et al.: Biol. Pharm. Bull., 26, 872 (2003),
Physical State
:
Solid
Solubility
:
Soluble in methanol.
保存方法
:
Store at 4° C
Melting Point
:
144-146° C
Boiling Point
:
~674.5° C at 760 mmHg (Predicted)
Density
:
~1.3 g/cm3 (Predicted)
Refractive Index
:
n20D 1.61 (Predicted)
Optical Activity
:
α20/D +19.5°±3.5°, c = 1 in methanol
IC50
:
ACE: IC50 = 2.8 nM (human)
pK Values
:
pKa: 2.19 (Predicted), pKb: 7.67 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID
:
107994
MDL Number
:
MFCD00865778
SMILES
:
C[[email protected]@H](C(=O)N1CC2=CC=CC=C2C[[email protected]]1C(=O)O)N[[email protected]@H](CCC3=CC=CC=C3)C(=O)O
Download SDS (MSDS)
分析表
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