PTP Inhibitor V, PHPS1 CAS: 314291-83-3
MF: C21H15N5O6S
MW: 465.45
A cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2.

PTP Inhibitor V, PHPS1 (CAS 314291-83-3)

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別名: PhenylHydrazonoPyrazolone Sulfonate 1
アプリケーション: PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2
CAS 番号: 314291-83-3
Purity: ≥95%
Molecular Weight: 465.45
Molecular Formula: C21H15N5O6S
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).

PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC50 = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. PTP Inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.


参考文献

1. Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105:7275-7280. PMID: 18480264

用法 :
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
保存方法 :
Store at 4° C
IC50 :
Shp-2: IC50 = 2.1 µM; EC50PTP: IC50 = 5.4 µM; PTP1B: IC50 = 19 µM; Shp1: IC50 = 30 µM; mycobacterium MptpA: IC50 = 39 µM
Ki Data :
Shp-2: Ki= 0.73 µM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
SMILES :
[S](O)(=O)(=O)CC4=CC=C(NN=C1C(=NN(C1=O)C2=CC=CC=C2)C3=CC=C(C=C3)C[N+]([O-])=O)C=C4

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PTP Inhibitor V, PHPS1 (CAS 314291-83-3)  参考文献

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PMID: # 30776010  Chen, CD. et al. 2019. J. Alzheimers Dis. 67: 1089-1106.

PMID: # 23189174  Tsang, YH. et al. 2012. PLoS ONE. 7: -.

PMID: # 22878065  Gupta, VK. et al. 2012. Biochim. Biophys. Acta. 1822: 1643-9.

PMID: # 31598397  Am J Cancer Res. 9: 1957-1969.

PMID: # 32054954  Sci Rep. 10: 2505.

PMID: # 27812544  JCI Insight. 1: e89020.

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