PTP Inhibitor V, PHPS1 (CAS 314291-83-3)

5.0(1)

別名: PhenylHydrazonoPyrazolone Sulfonate 1

アプリケーション： PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2

CAS 番号: 314291-83-3

Purity: ≥95%

Molecular Weight: 465.45

Molecular Formula: C₂₁H₁₅N₅O₆S

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* Refer to Certificate of Analysis for lot specific data (including water content).

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PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC₅₀ and K_i = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC₅₀ = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. PTP Inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.

参考文献

1. Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105:7275-7280. PMID: 18480264

用法 :

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Physical State :

Solid

Solubility :

Soluble in DMSO (10 mg/ml).

保存方法 :

Store at 4° C

IC50 :

Shp-2: IC₅₀ = 2.1 µM; EC₅₀PTP: IC₅₀ = 5.4 µM; PTP1B: IC₅₀ = 19 µM; Shp1: IC₅₀ = 30 µM; mycobacterium MptpA: IC₅₀ = 39 µM

Ki Data :

Shp-2: K_i= 0.73 µM

試験・研究用以外には使用しないでください。臨床及び体外診断には使用できません。

PubChem CID :

71433536

SMILES :

[S](O)(=O)(=O)CC4=CC=C(NN=C1C(=NN(C1=O)C2=CC=CC=C2)C3=CC=C(C=C3)C[N+]([O-])=O)C=C4

Download SDS (MSDS)

分析表

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