PTP CD45 Inhibitor 抑制剤 (CAS 345630-40-2)

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別名: Protein Tyrosine Phosphatase CD45 Inhibitor; N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide

アプリケーション： PTP CD45 Inhibitor is a cell permeable potent reversible inhibitor of CD45

CAS 番号: 345630-40-2

Purity: ≥97%

Molecular Weight: 307.34

Molecular Formula: C₁₉H₁₇NO₃

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* Refer to Certificate of Analysis for lot specific data (including water content).

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PTP CD45 Inhibitor: sc-222223. Immunofluorescence staining of methanol-fixed lambda protein...

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PTP CD45 Inhibitor is a cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC₅₀ = 200 nM or 3.8 μM using pNPP or phosphorylated Ick505 peptide as a substrate, respectively). PTP CD45 Inhibitor is not able to effectively inhibit PTPIB (IC₅₀ <30 μM using phosphorylated Ick505 peptide as a substrate). The phenanthrenedione group does not function as a thiol oxidizing agent.

参考文献

1. Urbanek, R.A., et al. 2001. J. Med. Chem. 44: 1777-1793. PMID: 11356112

Physical State :

Solid

Solubility :

Soluble in DMF (10 mg/ml), and DMSO (10 mg/ml).

保存方法 :

Store at 4° C

試験・研究用以外には使用しないでください。臨床及び体外診断には使用できません。

PubChem CID :

9926586

SMILES :

CC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C(=O)C2=O

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