PPIase-Parvulin 抑制剤 (CAS 64005-90-9)
別名:
PiB; HIC 016C; Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
アプリケーション：
PPIase-Parvulin Inhibitor is a Pin1/Pin4 PPIase activity inhibitor
CAS 番号:
64005-90-9
Purity:
≥95%
Molecular Weight:
438.4
Molecular Formula:
C22H18N2O8
補足情報:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PPIase-Parvulin Inhibitor is a cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties. PPIase-Parvulin Inhibitor causes cell cycle arrest and acts as a potent, competitive, selective, reversible, active site binding inhibitor of Pin1/Pin4 PPIase (peptidyl prolyl cis-trans isomerase) activity. It does not bind to DNA or functions as a topoisomerase I inhibitor.
参考文献
1. Uchida, Takafumi., et al., 2003. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chemistry & biology. 10(1): 15-24. PMID: 12573694
Physical State
:
Solid
Solubility
:
Soluble in chloroform (1 mg/ml), and ethanol (250 µg/ml, cloudy suspension).
保存方法
:
Store at 4° C
Melting Point
:
>300° C
Boiling Point
:
636.46° C at 760 mmHg (Predicted)
Density
:
1.47 g/cm3 (Predicted)
Refractive Index
:
n20D 1.64 (Predicted)
IC50
:
Pin1/Par14 PPIase : IC50 = ~ 1.5 µM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
Transport
:
UN 3077, Class 9, Packing group III
PubChem CID
:
SMILES
:
CCOC(=O)CN1C(=O)C2=C3C(=CC=C4C3=C(C=C2)C(=O)N(C4=O)CC(=O)OCC)C1=O
Download SDS (MSDS)
分析表
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