(±)-threo-3-Methylglutamic acid (CAS 63088-04-0)
別名:
(2R,3S)-2-amino-3-methylpentanedioic acid; T3MG; threo-3-Methylglutamate
アプリケーション：
(±)-threo-3-Methylglutamic acid is a glutamate transport blocker selective for EAAT2 and EAAT4
CAS 番号:
63088-04-0
Molecular Weight:
161.16
Molecular Formula:
C6H11NO4
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
(±)-threo-3-Methylglutamic acid is a potent blocker of glutamate transport. (±)-threo-3-Methylglutamic acid is selective for EAAT2 and EAAT4 (IC50 values are 90, 109, 1600 and 1080 μM for EAAT2, EAAT4, EAAT1 and EAAT3 respectively).
参考文献
Vandenberg et al (1997) Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol.Pharmacol. 51 809. Mitrovic et al (1998) Identification of functional domains of the human glutamate transpo
Appearance
:
Crystalline powder
Physical State
:
Solid
Solubility
:
Soluble in 1eq. NaOH (100 mM), and water (>1.5 mg/dL).
保存方法
:
Store at room temperature
Melting Point
:
226.22° C (Predicted)
Boiling Point
:
329.35° C at 760 mmHg (Predicted)
Density
:
1.33 g/cm3 (Predicted)
Refractive Index
:
n20D 1.51 (Predicted)
IC50
:
EAAT2: IC50 = 90 µM; EAAT4: IC50 = 109 µM; EAAT3: IC50 = 1080 µM; EAAT1: IC50 = 1600 µM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany
:
3
PubChem CID
:
MDL Number
:
MFCD09836097
SMILES
:
CC(CC(=O)O)C(C(=O)O)N
Download SDS (MSDS)
分析表
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