(±)-HIP-A (CAS 227619-64-9)
別名:
(±)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid
アプリケーション：
(±)-HIP-A is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker
CAS 番号:
227619-64-9
Molecular Weight:
172.14
Molecular Formula:
C6H8N2O4
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(±)-HIP-A is a potent, non-competitive EAAT (excitatory amino acid transporter) blocker. (±)-HIP-A preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.6 μM) rather than [3H]L-glutamate uptake (IC50 = 18 μM). The compound is moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC50 values are 43 and 8 μM respectively).
参考文献
1. Conti, P., et al. 1999. J. Med .Chem. 42: 4099-4107.
2. Funicello, M., et al. 2004. Mol. Pharmacol. 66:522-529.
Physical State
:
Solid
Solubility
:
Soluble in water (10 mM).
保存方法
:
Store at -20° C
IC50
:
Glutamate-induced [3H]D-aspartate release: IC50 = 1.6 µM; [3H]L-glutamate uptake: IC50 = 18 µM; AMPA receptors: IC50 = 43 µM; Kainate receptors: IC50 = 8 µM
pK Values
:
pKa: 1.92, pKb: 9.51
Download SDS (MSDS)
分析表
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