PLAP CAS: 137314-60-4
MF: C106H184N28O30
MW: 2330.8
A phospholipase A2 activating peptide fragment consisting of 21 residues.

PLAP (CAS 137314-60-4)

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同義語 Phospholipase A2 activating peptide
アプリケーション: A phospholipase A2 activating peptide fragment consisting of 21 residues
CAS 番号: 137314-60-4
Purity: ≥97%
Molecular Weight: 2330.8
Molecular Formula: C106H184N28O30
* Refer to Certificate of Analysis for lot specific data (including water content).
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The phospholipase A2 activating protein (PLAP) is a 21-residue fragment that spans the PLAP-melittin homology sequence and is a member of the β-transducin (Gβ) superfamily. The peptide activates phospholipase A2 (10-fold at 1 μg/ml) in BC3H1 cell sonicates, as well as stimulates Golgi membrane tubulation and retrograde trafficking to the ER. Research indicates that PLAP peptide activates Ca(2+)-dependent phospholipase A(2) cPLA(2) in vascular smooth muscle cells, leading to arachidonic acid release and apoptosis.


参考文献

1. Peitsch, M.C., 1993. Trends Biochem. Sci. 18: 292-293. PMID: 8236442
2. Wang, H., et al. 1995. Gene. 161: 237-241. PMID: 7665086
3. Polizotto, R.S., et al. 1999. J. Cell. Biochem. 74: 670-683. PMID: 10440936
4. Pilane, C.M., et al. 2004. J. Cell. Physiol. 198: 48-52. PMID: 14584043

Physical State :
Solid
Sequence :
H-Glu-Ser-Pro-Leu-Ile-Ala-Lys-Val-Leu-Thr-Thr-Glu-Pro-Pro-Ile- Ile-Thr-Pro-Val-Arg-Arg-OH
Solubility :
Soluble in water.
保存方法 :
Store at -20° C
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3

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