Pitavastatin Calcium (CAS 147526-32-7)

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別名: Pitavastatin hemicalcium; Nisvastatin

アプリケーション： Pitavastatin Calcium is a competitive inhibitor of HMG-CoA reductase

CAS 番号: 147526-32-7

Purity: ≥98%

Molecular Weight: 880.98

Molecular Formula: C₅₀H₄₆CaF₂N₂O₈

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* Refer to Certificate of Analysis for lot specific data (including water content).

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Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox (NADPH oxidase). In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187 (sc-3591). Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.

参考文献

1. Kajinami, K., et al. 2003. Cardiovasc Drug Rev. 21: 199-215. PMID: 12931254
2. Terata, Y., et al. 2003. Pharmacology. 68: 169-176. PMID: 12837970
3. Hayashi, T., et al. 2004. Atherosclerosis. 176: 255-263. PMID: 15380447
4. Takayama, T., et al. 2004. Circ. J. 68: 1067-1075. PMID: 15502390

Appearance :

Powder

Physical State :

Solid

Solubility :

Soluble in DMSO (100 mMl), water (<1 mg/ml), and ethanol (<1 mg/ml).

保存方法 :

Store at room temperature

Boiling Point :

692° C at 760 mmHg

試験・研究用以外には使用しないでください。臨床及び体外診断には使用できません。

PubChem CID :

5282451

SMILES :

O[[email protected]](/C=C/c1c(nc2ccccc2c1c1ccc(F)cc1)C1CC1)C[[email protected]@H](O)CC(=O)O[Ca]OC(=O)C[[email protected]](O)C[[email protected]](O)/C=C/c1c(nc2ccccc2c1c1ccc(F)cc1)C1CC1

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