Perillic Acid CAS: 23635-14-5
MF: C10H14O2
MW: 166.22
An apoptosis inducing agent via an increase in p21, Bax, and caspase-3 in cells.

Perillic Acid (CAS 23635-14-5)

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同義語 (S)-4-(1-Methylethenyl)-1-cyclohexene-1-carboxylic acid
アプリケーション: An apoptosis inducing agent via an increase in p21, Bax, and caspase-3 in cells
CAS 番号: 23635-14-5
Purity: 95%
Molecular Weight: 166.22
Molecular Formula: C10H14O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Perillic Acid, a metabolite of perillyl alcohol, has been shown to elicit cytotoxicity, induce cell cycle arrest and apoptosis via an increase in expression of p21, Bax, and caspase-3 activity in cells. This compound has also been found to be a major metabolite of d-limonene (sc-205283), a solvent of cholesterol. Perillic Acid has been noted to inhibit isoprenylation. Studies suggest that this agent has demonstrated the capacity to produce morphological changes to murine lens epithelial cells in culture and cause opacification of the lenses.


参考文献

1. Cheng, Q.F., et al. 2001. Exp. Eye Res. 73: 239-245. PMID: 11446774
2. Chow, H.H., et al. 2002. Cancer Epidemiol. Biomarkers Prev. 11: 1472-1476. PMID: 12433729
3. Yeruva, L., et al. 2007. Cancer Lett. 257: 216-226. PMID: 17888568

Physical State :
Solid
Solubility :
Soluble in DMSO, and ethanol.
保存方法 :
Store at 4° C
Melting Point :
129-131° C (lit.)
Boiling Point :
284.94° C at 760 mmHg
Density :
1.07 g/cm3
Refractive Index :
n20D 1.51
Optical Activity :
α20/D -102°, c = 2 in methanol
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
2724160
MDL Number :
MFCD00062539
EC Number :
231-709-5
SMILES :
CC(=C)[[email protected]]1CCC(=CC1)C(=O)O

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