Pelitinib (CAS 257933-82-7)
別名:
EKB 569
アプリケーション：
Pelitinib is an EGFR inhibitor
CAS 番号:
257933-82-7
Purity:
98%
Molecular Weight:
467.92
Molecular Formula:
C24H23ClFN5O2
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Pelitinib is a tyrosine kinase inhibitor that covalently binds to EGFR, inhibiting receptor phosphorylation and thus inhibiting signal transduction from EGFR. This induces apoptosis and thus leads to suppression of growth in tumor cell lines.
参考文献
Veronese, M., et al.: Br. J. Cancer, 92, 1846 (2005), Hofheinz, R., et al.: Onkologie, 29, 563 (2006), Meyerhardt, J., et al.: J. Clin. Oncol., 24, 1892 (2006), Hanauske, A., et al.: Clin. Cancer Res., 13, 523 (2007).
Physical State
:
Solid
Solubility
:
Soluble in DMSO (13 mg/ml at 25° C), methanol, water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
保存方法
:
Store at -20° C
Melting Point
:
188-190° C
Boiling Point
:
~655.5° C at 760 mmHg (Predicted)
Density
:
~1.3 g/cm3 (Predicted)
Refractive Index
:
n20D 1.65 (Predicted)
IC50
:
EGFR : IC50 = 38.5 nM; proliferation of normal human keratinocytes: IC50 = 61 nM; proliferation of A431 tumor cells: IC50 = 125 nM; proliferation ofMDA-468 tumor cells: IC50 = 260 nM
pK Values
:
pKa: 12.24 (Predicted), pKb: 8.01 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID
:
6445562
MDL Number
:
MFCD09837868
SMILES
:
CCOC1=C(NC(=O)\\C=C\\CN(C)C)C=C2C(=C1)N=CC(C#N)=C2NC1=CC(Cl)=C(F)C=C1
Download SDS (MSDS)
分析表
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