PEDF Antibody (LL-J): sc-74254
- PEDF Antibody (LL-J) is a mouse monoclonal IgG2b, cited in 1 publications, provided at 100 µg/ml
- raised against full length recombinant PEDF of human origin
- recommended for detection of PEDF of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PEDF Antibody (LL-J). This work is in progress.
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PEDF Antibody (LL-J) is a mouse monoclonal IgG2b light chain antibody that detects pigment epithelium-derived growth factor (PEDF) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PEDF is a crucial glycoprotein predominantly secreted by retinal pigment epithelium cells, playing a significant role in neuroprotection and neuronal differentiation. PEDF belongs to the serine protease inhibitor (Serpin) superfamily and inhibits angiogenesis and the proliferation of various cell types, making PEDF vital in maintaining ocular health and preventing pathological conditions such as diabetic retinopathy. Strategic localization of PEDF within the interphotoreceptor matrix allows PEDF to effectively influence the underlying neural retina, thereby enhancing neuroprotective effects. PEDF promotes the survival of central nervous system neurons, protecting neurons from degeneration induced by serum withdrawal or glutamate cytotoxicity, which underscores PEDF′s importance in neurobiology and potential therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PEDF Antibody (LL-J) References:
- PEDF and septic shock. | Nakamura, T. and Yamagishi, SI. 2010. Curr Mol Med. 10: 312-6. PMID: 20236051
- Structure-function relationships of PEDF. | Kawaguchi, T., et al. 2010. Curr Mol Med. 10: 302-11. PMID: 20236052
- PEDF-induced alteration of metabolism leading to insulin resistance. | Carnagarin, R., et al. 2015. Mol Cell Endocrinol. 401: 98-104. PMID: 25462587
- The Role of PEDF in Pancreatic Cancer. | Ansari, D., et al. 2019. Anticancer Res. 39: 3311-3315. PMID: 31262851
- Signaling Mechanisms Involved in PEDF-Mediated Retinoprotection. | Pagan-Mercado, G. and Becerra, SP. 2019. Adv Exp Med Biol. 1185: 445-449. PMID: 31884652
- Receptors that bind to PEDF and their therapeutic roles in retinal diseases. | Xu, M., et al. 2023. Front Endocrinol (Lausanne). 14: 1116136. PMID: 37139333
- Corrigendum to (title of manuscript): PEDF attenuates hypoxia-induced apoptosis and necrosis in H9c2 cells by inhibiting p53 mitochondrial translocation via PEDF-R. | Wang, X., et al. 2023. Biochem Biophys Res Commun. 689: 149159. PMID: 37985352
- PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD-like pathology in a murine model. | Xiang, W., et al. 2024. Geroscience. 46: 2697-2714. PMID: 38153666
- The Various Roles of PEDF in Cancer. | Elmi, M., et al. 2024. Cancers (Basel). 16: PMID: 38339261
- PEDF-34 attenuates neurological deficit and suppresses astrocyte-dependent neuroinflammation by modulating astrocyte polarization via 67LR/JNK/STAT1 signaling pathway after subarachnoid hemorrhage in rats. | Wu, L., et al. 2024. J Neuroinflammation. 21: 178. PMID: 39034417
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PEDF Antibody (LL-J) | sc-74254 | 100 µg/ml | $322.00 |