p70 S6 kinase β Antibody (164CT21.2.2): sc-517350
- p70 S6 kinase β Antibody (164CT21.2.2) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against a recombinant protein corresponding to p70 S6 kinase β of human origin
- recommended for detection of p70 S6 kinase β of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p70 S6 kinase β Antibody (164CT21.2.2). This work is in progress.
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p70 S6 kinase β Antibody (164CT21.2.2) is a mouse monoclonal IgG1 antibody that detects p70 S6 kinase β in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). p70 S6 kinase β plays a crucial role in the regulation of protein synthesis and cell growth by phosphorylating the ribosomal protein S6, which is essential for the translation of mRNAs that encode for proteins involved in cell cycle progression and metabolism. p70 S6 kinase β is primarily located in the cytoplasm, where activation occurs in response to growth factors and mitogenic signals, highlighting its importance in cellular signaling pathways that govern cell proliferation and survival. Activation of p70 S6 kinase β is tightly regulated by upstream signaling cascades, including the ERK MAP kinase pathway, which underscores its significance in various physiological processes and potential implications in cancer and metabolic disorders. Anti-p70 S6 kinase β antibody (164CT21.2.2) serves as an invaluable tool for researchers investigating the intricate mechanisms of cell signaling and the role of this kinase in health and disease.
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p70 S6 kinase β Antibody (164CT21.2.2) References:
- Immunohistochemical analysis of S6K1 and S6K2 expression in human breast tumors. | Savinska, LO., et al. 2004. Eksp Onkol. 26: 24-30. PMID: 15112576
- Clinical potential of the mTOR targets S6K1 and S6K2 in breast cancer. | Pérez-Tenorio, G., et al. 2011. Breast Cancer Res Treat. 128: 713-23. PMID: 20953835
- hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. | Roy, R., et al. 2014. Nucleic Acids Res. 42: 12483-97. PMID: 25324306
- Different interactomes for p70-S6K1 and p54-S6K2 revealed by proteomic analysis. | Pavan, IC., et al. 2016. Proteomics. 16: 2650-2666. PMID: 27493124
- Context-Specific Function of S6K2 in Th Cell Differentiation. | Pai, C., et al. 2016. J Immunol. 197: 3049-3058. PMID: 27613697
- Phosphorylation of Ser6 in hnRNPA1 by S6K2 regulates glucose metabolism and cell growth in colorectal cancer. | Sun, Y., et al. 2017. Oncol Lett. 14: 7323-7331. PMID: 29344170
- Modulation of hypothalamic S6K1 and S6K2 alters feeding behavior and systemic glucose metabolism. | Tavares, MR., et al. 2020. J Endocrinol. 244: 71-82. PMID: 31557728
- Loss of S6K1 But Not S6K2 in the Tumor Microenvironment Suppresses Tumor Growth by Attenuating Tumor Angiogenesis. | Lee, S., et al. 2020. Transl Oncol. 13: 100767. PMID: 32251993
- Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2). | Gerstenecker, S., et al. 2021. Cancers (Basel). 13: PMID: 34680283
- Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma. | Lipchick, B., et al. 2025. Sci Transl Med. 17: eadp8913. PMID: 39908352
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p70 S6 kinase β Antibody (164CT21.2.2) | sc-517350 | 100 µg/ml | $322.00 |