p-JNK抗体(9H8): sc-81502

4.8(4)

- p-JNK抗体 9H8はマウスモノクローナルIgG₁です。50 µg/0.5 mlで提供
- raised against phosphopeptide corresponding to amino acid residues surrounding the pThr-Gly/Pro-pTyr motif of JNK of human origin
- mouse, rat と human 由来のboth Tyr 185 phosphorylated JNK1, JNK2 and JNK3 and Thr 183 and Tyr 185 dually phosphorylated JNK1, JNK2 and JNK3 WB, IP, IF と ELISAでの検出にはお勧めします; non cross-reactive with the non-phosphorylated form of JNK
- p-JNK (G-7): sc-6254 p-JNK 抗体は、AC, HRP, FITC, PE, Alexa Fluor^® 488, 594, 647, 680 と 790標識された抗体も提供できます。
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-JNK Antibody (9H8). This work is in progress.

関連項目

ほかのJNK抗体、 JNK1, JNK2と JNK3を含め
JNK細胞応答の機能解析のためのChemCruz™ Chemical JNK 阻害剤又は JNK アクチベーター

The mitogen-activated protein (MAP) kinases ERK 1 and ERK 2 are proline-directed kinases that are activated through concomitant phosphorylation of tyrosine and threonine residues. The JNK family, which includes JNK1, JNK2, and JNK3, is distantly related to the MAP kinase family, members of which are activated by dual phosphorylation at a Thr-Pro-Tyr motif, specifically at Thr 183 and Tyr 185 residues, in response to ultraviolet (UV) light. This motif is divergent from the Thr-Glu-Tyr motif characteristic of the MAP kinase family. JNK is phosphorylated by JNK-activating kinase (JNKK1 and JNKK2), which are members of the MEK family. Activated JNK mediates the phosphorylation of c-Jun at the amino terminal serine regulatory sites, Ser 63 and Ser 73, which stimulates the transactivation function of c-Jun (5,6).

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

動物種	遺伝子名	Gene ID	Chromosome Location	Isoform (mRNA) Accession #	Protein Accession #	OMIM™ Number
Human	MAPK8	5599	10q11.22	NM_001278547, NM_001278548, NM_001323302, NM_001323320, NM_001323321, NM_001323322, NM_001323323, NM_001323324, NM_001323325, NM_001323326, NM_001323327, NM_001323328, NM_001323329, NM_001323330, NM_001323331, NM_139046, NM_139049, NM_002750	P45983	601158
Human	MAPK9	5601	5q35.3	XM_005265940, XM_006714891, XM_017009638, XM_017009639, XM_017009640, XM_017009641, XM_017009642, XM_017009643, NM_001135044, NM_001308244, NM_002752, NM_139068, NM_139069, NM_139070	P45984	602896
Human	MAPK10	5602	4q21.3	XM_005263129, XM_005263130, XM_005263131, XM_005263135, XM_006714268, XM_006714269, XM_011532117, XM_011532118, XM_011532120, XM_011532121, XM_017008419, XM_017008420, XM_017008421, XM_017008422, XM_017008423, XM_017008424, XM_017008425, XM_017008426, XM_017008427, XM_017008428, XM_017008429, XM_017008430, XM_017008431, XM_017008432, XM_017008433, XM_017008434, XM_017008435, XM_017008436, XM_017008437, XM_017008438, XM_017008439, XM_017008440, XM_017008441, XM_017008442, XM_017008443, XM_017008444, XM_017008445, XM_017008446, XM_017008447, XM_017008448, XM_017008449, XM_017008450, XM_017008451, XM_017008452, XM_017008453, XM_017008454, NM_001318067, NM_001318068, NM_001318069, NM_002753, NM_138980, NM_138982, NM_138981	P53779	606369
Human	MAPK11	5600	22q13.33	XM_011530706, NM_002751	Q15759	602898
Mouse	Mapk8	26419	14 B	XM_006519032, NM_001310452, NM_001310453, NM_001310454, NM_016700	Q91Y86	N/A
Mouse	Mapk14	26416	17 A3.3	XM_017317480, NM_001168508, NM_001168513, NM_001168514, NM_011951	P47811	N/A
Mouse	Mapk9	26420	11 B1.2	XM_017314562, XM_017314563, NM_001163671, NM_001163672, NM_016961, NM_207692	Q9WTU6	N/A
Mouse	Mapk10	26414	5 E5	XM_006534950, XM_011249450, XM_017320886, XM_017320888, XM_017320889, XM_017320890, XM_017320891, NM_001081567, NM_001310683, NM_001310685, NM_001310686, NM_001318102, NM_001318131, NM_009158	Q61831	N/A

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p-JNK抗体(9H8): sc-81502

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