raised against phosphopeptide corresponding to amino acid residues surrounding the pThr-Gly/Pro-pTyr motif of JNK of human origin
mouse, rat と human 由来のboth Tyr 185 phosphorylated JNK1, JNK2 and JNK3 and Thr 183 and Tyr 185 dually phosphorylated JNK1, JNK2 and JNK3 WB, IP, IF と ELISAでの検出にはお勧めします; non cross-reactive with the non-phosphorylated form of JNK
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The mitogen-activated protein (MAP) kinases ERK 1 and ERK 2 are proline-directed kinases that are activated through concomitant phosphorylation of tyrosine and threonine residues. The JNK family, which includes JNK1, JNK2, and JNK3, is distantly related to the MAP kinase family, members of which are activated by dual phosphorylation at a Thr-Pro-Tyr motif, specifically at Thr 183 and Tyr 185 residues, in response to ultraviolet (UV) light. This motif is divergent from the Thr-Glu-Tyr motif characteristic of the MAP kinase family. JNK is phosphorylated by JNK-activating kinase (JNKK1 and JNKK2), which are members of the MEK family. Activated JNK mediates the phosphorylation of c-Jun at the amino terminal serine regulatory sites, Ser 63 and Ser 73, which stimulates the transactivation function of c-Jun (5,6).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.