Neuritin Antibody (B-9): sc-365538

Neuritin Antibody (B-9) is a mouse monoclonal IgM kappa antibody that detects Neuritin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Neuritin antibody (B-9) is available as the non-conjugated form. Neuritin plays a crucial role in neuronal plasticity, as Neuritin (B-9) monoclonal antibody recognizes a glycosylphosphatidylinositol-anchored protein induced by neural activity and neurotrophins such as brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). Neuritin protein is primarily located in the extracellular space, where Neuritin modulates neurite growth, making Neuritin essential for the development and maintenance of neuronal connections. Neuritin′s presence in both developing and adult nervous systems highlights Neuritin′s importance in facilitating synaptic plasticity and neuronal survival. Additionally, Neuritin′s expression is influenced by external stimuli, such as light stimulation of the visual cortex, indicating Neuritin′s potential role in sensory processing and adaptation. By understanding Neuritin′s function and significance, researchers can gain insights into mechanisms underlying neurodevelopmental processes and neurodegenerative diseases, making anti-Neuritin antibody (B-9) a valuable tool for studying these complex biological phenomena.

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Neuritin Antibody (B-9) References:

1. Neuronal plasticity after spinal cord injury: identification of a gene cluster driving neurite outgrowth.  |  Di Giovanni, S., et al. 2005. FASEB J. 19: 153-4. PMID: 15522907
2. Androgen-induced neurite outgrowth is mediated by neuritin in motor neurones.  |  Marron, TU., et al. 2005. J Neurochem. 92: 10-20. PMID: 15606892
3. Coordinated motor neuron axon growth and neuromuscular synaptogenesis are promoted by CPG15 in vivo.  |  Javaherian, A. and Cline, HT. 2005. Neuron. 45: 505-12. PMID: 15721237
4. The changing scene of neurotrophic factors.  |  Thoenen, H. 1991. Trends Neurosci. 14: 165-70. PMID: 1713715
5. Cell death during development of the nervous system.  |  Oppenheim, RW. 1991. Annu Rev Neurosci. 14: 453-501. PMID: 2031577
6. Functions and the related signaling pathways of the neurotrophic factor neuritin.  |  Yao, JJ., et al. 2018. Acta Pharmacol Sin. 39: 1414-1420. PMID: 29595190
7. Follicular regulatory T cells produce neuritin to regulate B cells.  |  Gonzalez-Figueroa, P., et al. 2021. Cell. 184: 1775-1789.e19. PMID: 33711260
8. Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction.  |  Zhang, Z., et al. 2021. J Mol Endocrinol. 66: 259-272. PMID: 33729996
9. Fusion with CTP increases the stability of recombinant neuritin.  |  Meng, P., et al. 2023. Protein Expr Purif. 212: 106344. PMID: 37567400
10. Role of neurotrophins in mouse neuronal development.  |  Klein, R. 1994. FASEB J. 8: 738-44. PMID: 8050673
11. The conservation of neurotrophic factors during vertebrate evolution.  |  Götz, R. and Schartl, M. 1994. Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 108: 1-10. PMID: 8061955
12. Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis.  |  Naeve, GS., et al. 1997. Proc Natl Acad Sci U S A. 94: 2648-53. PMID: 9122250

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Neuritin Antibody (B-9) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Neuritin Antibody (B-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Neuritin Antibody (B-9) Specifications

Alternate Product Name: Neuritin

Product Clone Name: B-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 42-67

Epitope Target: Neuritin

Epitope Species: human

Product Reactivity/Detection: Neuritin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Neuritin Antibody (B-9): P: Blocking Peptide