Neuregulin-3 Antibody (D-3): sc-390171
- Neuregulin-3 Antibody (D-3) is a mouse monoclonal IgG2a κ Neuregulin-3 antibody provided at 200 µg/ml
- raised against amino acids 276-345 mapping within an N-terminal extracellular domain of Neuregulin-3 of human origin
- Neuregulin-3 Antibody (D-3) is recommended for detection of Neuregulin-3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and bovine
- Anti-Neuregulin-3 Antibody (D-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP is the preferred secondary detection reagent for Neuregulin-3 Antibody (D-3) for WB applications. This reagent is now offered in a bundle with Neuregulin-3 Antibody (D-3) (see ordering information below).
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SEE ALSO...
Neuregulin-3 Antibody (D-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects Neuregulin-3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Neuregulin-3 antibody (D-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Neuregulin-3, a member of the neuregulin family, plays a crucial role in regulating cell signaling pathways that influence growth and differentiation of various cell types, including glial, epithelial, and muscle cells. Neuregulin-3 is particularly important due to involvement in activating ErbB-3 and ErbB-4 receptor tyrosine kinases, which are essential for proper neural development and formation of neuromuscular junctions. Neuregulin-3 (D-3) monoclonal antibody has proven valuable in studying expression in breast cancer cell lines, suggesting a potential role as a regulator in both normal and malignant breast epithelial cells, making Neuregulin-3 a significant target for cancer biology research. The diverse functions of neuregulins, including modulating receptor activity and influencing cellular responses, underscore Neuregulin-3′s importance in both physiological and pathological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Neuregulin-3 Antibody (D-3) References:
- Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. | Harari, D., et al. 1999. Oncogene. 18: 2681-9. PMID: 10348342
- Identification of heregulin, a specific activator of p185erbB2. | Holmes, WE., et al. 1992. Science. 256: 1205-10. PMID: 1350381
- Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. | Coussens, L., et al. 1985. Science. 230: 1132-9. PMID: 2999974
- Growth factor receptor tyrosine kinases. | Yarden, Y. and Ullrich, A. 1988. Annu Rev Biochem. 57: 443-78. PMID: 3052279
- Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. | Sliwkowski, MX., et al. 1994. J Biol Chem. 269: 14661-5. PMID: 7514177
- Heregulin induces tyrosine phosphorylation of HER4/p180erbB4. | Plowman, GD., et al. 1993. Nature. 366: 473-5. PMID: 7902537
- A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. | Carraway, KL. and Cantley, LC. 1994. Cell. 78: 5-8. PMID: 8033211
- Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. | Marchionni, MA., et al. 1993. Nature. 362: 312-8. PMID: 8096067
- The erbB3 gene product is a receptor for heregulin. | Carraway, KL., et al. 1994. J Biol Chem. 269: 14303-6. PMID: 8188716
- Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. | Carraway, KL., et al. 1997. Nature. 387: 512-6. PMID: 9168115
- Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. | Zhang, D., et al. 1997. Proc Natl Acad Sci U S A. 94: 9562-7. PMID: 9275162
- NRG-3 in human breast cancers: activation of multiple erbB family proteins. | Hijazi, MM., et al. 1998. Int J Oncol. 13: 1061-7. PMID: 9772300
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Neuregulin-3 Antibody (D-3) | sc-390171 | 200 µg/ml | $322.00 | |||
Neuregulin-3 Antibody (D-3): m-IgG2a BP-HRP Bundle | sc-545957 | 200 µg Ab; 10 µg BP | $361.00 | |||
Neuregulin-3 Antibody (D-3) AC | sc-390171 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Neuregulin-3 Antibody (D-3) HRP | sc-390171 HRP | 200 µg/ml | $322.00 | |||
Neuregulin-3 Antibody (D-3) FITC | sc-390171 FITC | 200 µg/ml | $336.00 | |||
Neuregulin-3 Antibody (D-3) PE | sc-390171 PE | 200 µg/ml | $349.00 | |||
Neuregulin-3 Antibody (D-3) Alexa Fluor® 488 | sc-390171 AF488 | 200 µg/ml | $364.00 | |||
Neuregulin-3 Antibody (D-3) Alexa Fluor® 546 | sc-390171 AF546 | 200 µg/ml | $364.00 | |||
Neuregulin-3 Antibody (D-3) Alexa Fluor® 594 | sc-390171 AF594 | 200 µg/ml | $364.00 | |||
Neuregulin-3 Antibody (D-3) Alexa Fluor® 647 | sc-390171 AF647 | 200 µg/ml | $364.00 | |||
Neuregulin-3 Antibody (D-3) Alexa Fluor® 680 | sc-390171 AF680 | 200 µg/ml | $364.00 | |||
Neuregulin-3 Antibody (D-3) Alexa Fluor® 790 | sc-390171 AF790 | 200 µg/ml | $364.00 |