N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) CAS: 139332-94-8
MF: C25H41NO3S
MW: 435.7
A methyltransferase substrate.

N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) (CAS 139332-94-8)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 126ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
アプリケーション: A methyltransferase substrate
CAS 番号: 139332-94-8
Purity: ≥98%
Molecular Weight: 435.7
Molecular Formula: C25H41NO3S
* Refer to Certificate of Analysis for lot specific data (including water content).
この製品のレビューを提出し、15 CruzCreditsを受け取ります

N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) is a substrate for the carboxyl methyltransferase that is shown to inhibit Ras carboxyl methylation. The Ras subfamily is usually responsible for cell proliferation and inhibition of it will cause a halt in cell division. This compound has been noted to also be a competitive inhibitor for prenylcysteine methyl transferase which doubles the rate of basal and stimulates insulin secretion in a reversible and ATP-dependent manner. Additionally, this agent has been found to inhibit Integrin β2-induced actin polymerization in neutrophils.


1. Volker, C., et al. 1991. FEBS Lett. 295: 189-194. PMID: 1765152
2. Philips, M.R., et al. 1993. Science. 259: 977-980. PMID: 8438158
3. Regazzi, R., et al. 1995. Biochim. Biophys. Acta. 1268: 269-278. PMID: 7548225

Appearance :
Viscous oil
Physical State :
Solubility :
Soluble in DMSO (>25 mg/ml), 100% ethanol (>25 mg/ml), ethyl acetate, water (11 mg/ml) at 25° C, 0.1M Na2CO3 (11 mg/ml), and DMF (~33 mg/ml).
保存方法 :
Store at -20° C
Refractive Index :
n20D 1.52
IC50 :
Signal transduction that are receptor mediated: IC50 = 4 µM (human neutrophils); b2-integrin-induced actin polymerization: IC50 = ~45 nM (neutrophils)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
PubChem CID :
MDL Number :
EC Number :

Download SDS (MSDS)


Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC)  参考文献

See how others have used N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27710830  Zhao, Y. et al. 2016. Eur. J. Cancer. 68: 38-50.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 169ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 13ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

サンタクルーズバイオテクノロジーは生物医学研究市場向けの製品の開発における世界的リーダです。 下記フリー ダイヤルにお電話ください: 1-800-457-3801。Copyright © 2007-2020 Santa Cruz Biotechnology, Inc.全著作権所有。"Santa Cruz Biotechnology"、 及びSanta Cruz Biotechnology, Inc. ロゴ、 "Santa Cruz Animal Health"、 "San Juan Ranch"、 "Supplement of Champions"、 San Juan Ranch ロゴ、 "Ultracruz"、 "Chemcruz"、 "Immunocruz"、 "Exactacruz"、 と "EZ Touch"はサンタクルーズバイオテクノロジーの登録商標です。 商標はそれぞれの所有者に帰属します。