N-Acetyl-S-farnesyl-L-cysteine (AFC) CAS: 135304-07-3
MF: C20H33NO3S
MW: 367.55
An inhibitor of S-farnesylcysteine methyl transferase.

N-Acetyl-S-farnesyl-L-cysteine (AFC) (CAS 135304-07-3)

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同義語 AFC
アプリケーション: An inhibitor of S-farnesylcysteine methyl transferase
CAS 番号: 135304-07-3
Purity: ≥98%
Molecular Weight: 367.55
Molecular Formula: C20H33NO3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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N-Acetyl-S-farnesyl-L-cysteine is a synthetically derivatized cysteine amino acid inhibitor of S-farnesylcysteine carboxyl methyltransferase enzymes. These enzymes recognize N-Acetyl-S-farnesyl-L-cysteine as a substrate through the farnesyl moiety, and occupation of the binding site blocks processing of farnesylated proteins by the enzyme. Carboxyl methylation of farnesylated proteins is an important modification that regulates protein function. Blockade of methyltransferase processing of platelet rap1 proteins by N-Acetyl-S-farnesyl-L-cysteine leads to inhibition of platelet aggregation. N-Acetyl-S-farnesyl-L-cysteine is also described to block the cellular movement and membrane adhesion of Ras proteins by interfering with carboxyl methylation processing. N-Acetyl-S-farnesyl-L-cysteine as a substrate for isoprenylated protein methyltransferase is described to block fMet-Leu-Phe-stimulated release of superoxide radical anion in neutrophil cells. Inhibition of neutrophil chemotaxis by N-Acetyl-S-farnesyl-L-cysteine also produces suppression of inflammatory response induced by 12-O-tereadecanoyl-phorbol-13-acetate and arachidonic acid.


参考文献

1. Volker, C., et al. 1991. J. Biol. Chem. 266: 21515-21522. PMID: 1939182
2. Huzoor-Akbar, D.A., et al. 1991. J. Biol. Chem. 266: 4387-4391. PMID: 1900293
3. Pérez-Sala, D., et al. 1991. Proc. Natl. Acad. Sci. U.S.A. 88: 3043-3046. PMID: 1901651
4. Huzoor-Akbar, W., et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 868-872. PMID: 8430099
5. Philips, M.R., et al. 1993. Science. 259: 977-980. PMID: 8438158
6. Ding, J., et al. 1994. J. Biol. Chem. 269: 16837-16844. PMID: 8207006
7. Gordon, J.S., et al. 2008. J. Invest. Dermatol. 128: 643-654. PMID: 17882268

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), DMF (~20 mg/ml), 0.1 M Na2CO3 (63 mg/ml), PBS (pH 7.2), and water (63 mg/ml) at 25° C.
保存方法 :
Store at -20° C
Density :
1.04 g/mL
Refractive Index :
n20D 1.52
Ki Data :
S-farnesylcysteine methyl transferase: Ki= 20 µM
pK Values :
pKa: 3.31
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
1994
MDL Number :
MFCD00871540
SMILES :
CC(=CCCC(=CCCC(=CCSCC(C(=O)O)NC(=O)C)C)C)C

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