Lithium Chloride CAS: 7447-41-8
MF: LiCl
MW: 42.39
For assays to study cell-fate, neurobiology and antiviral properties; noted to inhibit GSK-3β.

Lithium Chloride (CAS 7447-41-8)

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別名: LiCl
アプリケーション: Lithium Chloride is for assays to study cell-fate, neurobiology and antiviral properties; noted to inhibit GSK-3β
CAS 番号: 7447-41-8
Purity: ≥99%
Molecular Weight: 42.39
Molecular Formula: LiCl
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Lithium Chloride is an antiviral metal halide utilized in a variety of assays to study cell-fate and neurobiology. In developing Xenopus embryos, lithium chloride is observed to exert inhibition of GSK-3β (glycogen synthase kinase-3β), yet not reported to be a general inhibitor of other protein kinases. These observations may have implications for lithium chloride on cell-fate determination in several organisms including Xenopus and Dictyostelium. Additionally, in transfected Chinese Hamster Ovary cells (CHO) stimulated with angiotension II (Ang II), it was noted that lithium chloride enhanced the production of inositol triphosphate. The antiviral properties of lithium chloride were noted in a study which showed that the compound inhibited pseudorabis virus infection in vitro. In Drosophila, it was observed that in the nervous system, lithium chloride may have an effect on amino acid metabolism. Futhermore, in glial primary cell cultures, lithium chloride has been noted to provide protection against glutamate excitotoxicity by potentially reducing NR1 mRNA, the major N-methyl-D-aspartate receptor (NMDAR) subunit in the cells.


参考文献

1. Klein, P.S., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 8455-8459. PMID: 8710892
2. Chrétien, L., et al. 1997. Cell. Signal. 9: 379-382. PMID: 9376218
3. Adler, J.T., et al. 2009. Ann. Surg. Oncol. 16: 481-486. PMID: 19030935
4. Zhuang, J., et al. 2009. Biochem. Biophys. Res. Commun. 380: 650-654. PMID: 19285016
5. Kasuya, J., et al. 2009. Neurosci. Res. 64: 413-420. PMID: 19410610
6. Sui, X., et al. 2010. Antiviral Res. 85: 346-353. PMID: 19879899

Physical State :
Solid
Solubility :
Soluble in water (1 mg/ml), alcohol, ether, pyridine, nitrobenzene, acetone, and amyl alcohol.
保存方法 :
Store at room temperature
Melting Point :
605° C (lit.)
Boiling Point :
1360° C
Density :
2.07 g/cm3 at 20° C
Ki Data :
GSK-3β: Ki= 2 mM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
1
RTECS :
OJ5950000
PubChem CID :
433294
Merck Index :
14: 5528
MDL Number :
MFCD00011078
EC Number :
231-212-3
SMILES :
[Li+].[Cl-]

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Lithium Chloride (CAS 7447-41-8)  参考文献

See how others have used Lithium Chloride (CAS 7447-41-8). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25992601  Legastelois, R. et al. 2015. PLoS ONE. 10: e0127408.

PMID: # 26544793  Lapp, T. et al. 2015. Investigative ophthalmology & visual science. 56: 7250-9.

Citations 1 to 2 of 2 total
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