KLK7 Antibody (1407): sc-80148
- KLK7 Antibody (1407) is a mouse monoclonal IgG2a, cited in 3 publications, provided at 100 µg/ml
- raised against amino acids 23-252 of KLK7 of human origin
- recommended for detection of KLK7 of human origin by WB and IP; non cross-reactive with KLK1,3-6 or 8-15
- also provided azide-free for neutralizing and blocking, sc-80148 L, 100 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for KLK7 Antibody (1407). This work is in progress.
KLK7 Antibody (1407) is a mouse monoclonal IgG2a light chain antibody that detects kallikrein 7 (KLK7) in human samples through western blotting (WB) and immunoprecipitation (IP). KLK7 is a member of the kallikrein family of serine proteases, which play crucial roles in various physiological processes, including the regulation of blood pressure, inflammation, and tissue remodeling. Anti-KLK7 antibody (1407) specifically recognizes KLK7 primarily expressed in the skin, where KLK7 participates in the proteolytic processing of extracellular matrix components essential for maintaining skin integrity and function. KLK7 monoclonal antibody (1407) enables research into KLK7′s potential role in skin disorders and cancer, as aberrant expression of kallikreins has been linked to tumor progression and metastasis. KLK7 is also implicated in the activation of other proteases, highlighting KLK7′s significance in proteolytic cascades that influence cellular behavior and tissue homeostasis. KLK7 (1407) antibody serves as a valuable tool for researchers investigating the biological functions and clinical implications of this important protease.
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KLK7 Antibody (1407) References:
- Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer. | Walker, F., et al. 2014. Biol Chem. 395: 1075-86. PMID: 25153388
- Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells. | Raju, I., et al. 2016. Biol Chem. 397: 1135-1146. PMID: 27279059
- Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer. | Gong, W., et al. 2020. J Ovarian Res. 13: 125. PMID: 33087135
- EGR-1 acts as a transcriptional activator of KLK7 under IL-13 stimulation. | Yeo, H., et al. 2021. Biochem Biophys Res Commun. 534: 303-309. PMID: 33276948
- Analysis of expression and prognosis of KLK7 in ovarian cancer. | Chen, E., et al. 2020. Open Med (Wars). 15: 932-939. PMID: 33336051
- Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis. | Chavarria-Smith, J., et al. 2022. Sci Transl Med. 14: eabp9159. PMID: 36516271
- Αnti-KLK5/KLK7 Antibody-based Strategies for the Treatment of Epidermal Diseases. | Pampalakis, G. 2023. Curr Pharm Des. 29: 2354-2357. PMID: 37987118
- A pharmacogenetic study of psoriasis supports the association between a gene (KLK7) and treatment response. | . 2023. Br J Dermatol. 190: e8. PMID: 38124525
- KLK7 expression in human tumors: a tissue microarray study on 13,447 tumors. | Kind, S., et al. 2024. BMC Cancer. 24: 794. PMID: 38961454
- KLK7 Involvement in Thyroid Papillary Carcinoma Cell Migration and Invasion by EMT via MAPK/ERK Pathways. | Li, M., et al. 2025. J Cancer. 16: 1709-1725. PMID: 39991575
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KLK7 Antibody (1407) | sc-80148 | 100 µg/ml | $322.00 | |||
KLK7 Antibody (1407) L | sc-80148 L | 100 µg/0.1 ml |