Ilimaquinone CAS: 71678-03-0
MF: C22H30O4
MW: 358.47
An ADP-ribosylation factor (ARF) and β-COP to the Golgi membrane inhibitor.

Ilimaquinone (CAS 71678-03-0)

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同義語 3-[(Decahydro-1β,2β,4αβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone;Imaquinone
アプリケーション: An ADP-ribosylation factor (ARF) and β-COP to the Golgi membrane inhibitor
CAS 番号: 71678-03-0
Purity: ≥98%
Molecular Weight: 358.47
Molecular Formula: C22H30O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ilimaquinone is a natural marine metabolite shown to have antiinflammatory, antimicrobial, and antimitotic properties. Ilimaquinone has also been described to block diptheria toxin and the cytotoxicity of ricin. Golgi membrane studies reveal that exposure to ilimaquinone results in the formation of vesiculated Golgi membranes and blockage of the secretory pathway, which can be reversed with the removal of ilimaquinone. Additionally, ilimaquinone has been shown to block the association of the ADP-ribosylation factor (ARF) and β-COP to the Golgi membrane, and depolarize cytoplasmic microtubules. Further studies report that the vesiculation of Golgi membranes through Ilimaquinone takes place by the activation of heterotrimeric G proteins. Biochemical assays from HIV studies suggest that ilimaquinone belongs to a group of marine metabolites with anti-HIV activity. Ilimaquinone studies suggest that it has the ability to induce anti-proliferative affects through GADD153-mediated pathway modifications.


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Physical State :
Solubility :
Soluble in DMSO (25 mg/ml), and ethanol (25 mg/ml).
保存方法 :
Store at -20° C
Melting Point :
204.22° C (Predicted)
Boiling Point :
~478.4° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.55
IC50 :
P388: IC50 = 0.2 ug/ml (Mus musculus); A549: IC50 = 0.4 ug/ml (human); A2780: IC50 = 10.9 µM (human); Adenosylhomocysteinase: IC50 = 40 µM (human)
pK Values :
pKa: 2.92
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
PubChem CID :
Merck Index :
14: 4898
MDL Number :
C[[email protected]]1CC[[email protected]]2([[email protected]]([[email protected]]1(C)CC3=C(C(=O)C=C(C3=O)OC)O)CCCC2=C)C

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Ilimaquinone  参考文献

See how others have used Ilimaquinone. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27281477  Massarweh, A. et al. 2016. J. Lipid Res. 57: 1477-91.

Citations 1 to 1 of 1 total
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