Hydroxychloroquine Sulfate (CAS 747-36-4)

Hydroxychloroquine sulfate is a compound extensively utilized in biochemical and cell biology research due to its ability to modulate cellular processes. It is a subject of interest in studies investigating autophagy, a cellular degradation pathway, as it can act as an autophagy inhibitor, affecting the lysosomal pH and enzyme activity. In the field of immunology, researchers examine the potential of hydroxychloroquine sulfate to influence immune cell function, particularly in the context of inflammation. Additionally, its role in the stabilization of biological membranes is explored, which can provide insight into cellular signaling and trafficking mechanisms. Research involving hydroxychloroquine sulfate also extends to its interaction with nucleic acids, helping to elucidate its effects on DNA replication and transcription processes within cells.

Hydroxychloroquine Sulfate (CAS 747-36-4) 参考文献

1. Development, validation and clinical application of a LC-MS/MS method for the simultaneous quantification of hydroxychloroquine and its active metabolites in human whole blood.  |  Soichot, M., et al. 2014. J Pharm Biomed Anal. 100: 131-137. PMID: 25165008
2. Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS-evaluation of whole blood, plasma, and serum as sample matrices.  |  Carlsson, H., et al. 2020. Arthritis Res Ther. 22: 125. PMID: 32475347
3. Validation of a liquid chromatography tandem mass spectrometry method for the simultaneous determination of hydroxychloroquine and metabolites in human whole blood.  |  Austin, D., et al. 2020. Clin Chem Lab Med. 58: 2047-2061. PMID: 32915766
4. A Strategy to Treat COVID-19 Disease With Targeted Delivery of Inhalable Liposomal Hydroxychloroquine: A Preclinical Pharmacokinetic Study.  |  Tai, TT., et al. 2021. Clin Transl Sci. 14: 132-136. PMID: 33135382
5. Pharmacokinetics and Toxicokinetics of Artemisinin-Hydroxychloroquine Sulfate Tablets in Rats and Dogs.  |  Li, X., et al. 2021. Evid Based Complement Alternat Med. 2021: 6830459. PMID: 34721641