HC Toxin CAS: 83209-65-8
MF: C21H32N4O6
MW: 436.5
An HDAC inhibitor.

HC Toxin (CAS 83209-65-8)

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同義語 Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-]
アプリケーション: An HDAC inhibitor
CAS 番号: 83209-65-8
Molecular Weight: 436.5
Molecular Formula: C21H32N4O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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HC Toxin is a potent, cell-permeable HDAC (histone deacetylase) inhibitor. HC Toxin inhibits HDACs in maize, Physarum and chicken. HC Toxin has displayed antiprotozoal and antineoplastic activity. HC toxin has induced the expression of the gamma-globin gene in erythroid cells. Antiproliferative activity against T47D human breast cancer cells and cultured mastocytoma cells has been observed with HC toxin treatment.


参考文献

1. Walton, J D., et al., 1985. Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin. Experientia. 41(3): 348-50. PMID: 3918884
2. Brosch, G., et al., 1995. Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum. The Plant cell. 7(11): 1941-50. PMID: 8535144
3. Ross, J., et al., 1996. Comments on the article "Persistent confusion of total entropy and chemical system entropy in chemical thermodynamics" [(1996) Proc. Natl. Acad. Sci. USA 93, 7452-7453]. Proceedings of the National Academy of Sciences of the United States of America. 93(25): 14314; discussion 14315. PMID: 8962046
4. McCaffrey, P G., et al., 1997. Induction of gamma-globin by histone deacetylase inhibitors. Blood. 90(5): 2075-83. PMID: 9292546
5. Joung, Ki Eun., et al., 2004. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. Archives of pharmacal research. 27(6): 640-5. PMID: 15283467
6. Walton, Jonathan D., et al., 2006. HC-toxin. Phytochemistry. 67(14): 1406-13. PMID: 16839576

Physical State :
Solid
Derived From :
Helminthosporium carbonium
Solubility :
Soluble in DMSO.
保存方法 :
Store at -20° C
Boiling Point :
819.18° C at 760 mmHg (Predicted)
Density :
1.29 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
E. tenella HDAC: IC50 = 30 nM; Histone deacetylase 11: IC50 = 430 nM (human)
pK Values :
pKa: 13.33
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
23724535
MDL Number :
MFCD00133388
SMILES :
CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C)CCCCCC(=O)C3CO3

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HC Toxin  参考文献

See how others have used HC Toxin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24227836  Shin, HJ. et al. 2014. J. Virol. 88: 1281-92.

Citations 1 to 1 of 1 total
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