Golgicide A CAS: 1005036-73-6
MF: C17H14F2N2
MW: 284.30
A potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1.

Golgicide A (CAS 1005036-73-6)

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別名: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
アプリケーション: Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1
CAS 番号: 1005036-73-6
Purity: ≥98%
Molecular Weight: 284.30
Molecular Formula: C17H14F2N2
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Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, which decreases Arf1 activation. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. The Arf activity cycle is initiated by the interaction of Arf1 with guanine nucleotide exchange factors (GEFs), which exchange GDP for GTP. Molecular modeling and mutagenesis revealed that Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. It is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.


参考文献

Sáenz, J.B., et al., Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem. Biol., (2009)

Physical State :
Solid
保存方法 :
Store at room temperature
Boiling Point :
~383° C at 760 mmHg (Predicted)
Density :
1.26 g/cm3 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
SMILES :
C1C=C[[email protected]]2[[email protected]@H]1C(NC3=C(C=C(C=C23)F)F)C4=CN=CC=C4

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Golgicide A (CAS 1005036-73-6)  参考文献

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PMID: # 28485883  Ignashkova, TI. et al. 2017. Traffic. 18: 530-544.

PMID: # 28536105  Ramírez-Peinado, S. et al. 2017. J. Cell. Sci. 130: 2251-2265.

PMID: # 28463988  Calton, CM.|Bronnimann, MP.|Manson, AR.|Li, S.|Chapman, JA.|Suarez-Berumen, M.|Williamson, TR.|Molugu, SK.|Bernal, RA.|Campos, SK.| et al. 2017. PLoS Pathog. 13: e1006200.

PMID: # 29074567  Gendarme, M. et al. 2017. Mol. Biol. Cell.

PMID: # 28981087  van Raam, BJ. et al. 2017. Cell Death Dis. 8: e3069.

PMID: # 29118074  Baumann, J. et al. 2017. Mol. Biol. Cell.

PMID: # 24185178  Reiling, JH. et al. 2013. Nature cell biology. 15: 1473-85.

PMID: # 27680705  Nature. 109-113.

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