GM-CSF Antibody (H-3): sc-398649
- GM-CSF Antibody (H-3) is a mouse monoclonal mouse IgM κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 117-141 at the C-terminus of GM-CSF of mouse origin
- recommended for detection of GM-CSF of mouse and rat origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GM-CSF Antibody (H-3). This work is in progress.
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GM-CSF Antibody (H-3) is a mouse monoclonal IgM antibody that detects granulocyte-macrophage colony stimulating factor (GM-CSF) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GM-CSF is a crucial pleiotropic cytokine that plays a significant role in the proliferation and differentiation of hematopoietic progenitor cells, particularly influencing the development of granulocytes and macrophages. The mature form of GM-CSF consists of 127 amino acids in humans and 124 amino acids in mice, with a notable 60% homology between the two species. GM-CSF undergoes post-translational modifications, including glycosylation, which enhances stability and bioactivity. The glycosylation of GM-CSF is essential for interaction with specific receptors on target cells, facilitating the signaling pathways that lead to the activation and proliferation of immune cells. Anti-GM-CSF antibody (H-3) is an invaluable tool for researchers studying immune responses and hematopoiesis, providing insights into the mechanisms of action and regulation of this important cytokine.
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GM-CSF Antibody (H-3) References:
- G-CSF and GM-CSF for treating or preventing neonatal infections. | Carr, R., et al. 2003. Cochrane Database Syst Rev. 2003: CD003066. PMID: 12917944
- GM-CSF regulation of embryo development and pregnancy. | Robertson, SA. 2007. Cytokine Growth Factor Rev. 18: 287-98. PMID: 17512774
- G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis. | Cornish, AL., et al. 2009. Nat Rev Rheumatol. 5: 554-9. PMID: 19798030
- GM-CSF promotes migration of human monocytes across the blood brain barrier. | Vogel, DY., et al. 2015. Eur J Immunol. 45: 1808-19. PMID: 25756873
- GM-CSF has disparate roles during intranasal and intradermal Francisella tularensis infection. | Kurtz, SL., et al. 2016. Microbes Infect. 18: 758-767. PMID: 27475899
- Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis. | Ramadass, M., et al. 2017. J Leukoc Biol. 101: 693-702. PMID: 27733578
- GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism. | Na, YR., et al. 2016. J Immunol. 197: 4101-4109. PMID: 27742831
- Targeting the GM-CSF receptor for the treatment of CNS autoimmunity. | Ifergan, I., et al. 2017. J Autoimmun. 84: 1-11. PMID: 28641926
- The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities. | Dhagat, U., et al. 2018. MAbs. 10: 1018-1029. PMID: 29969365
- GM-CSF intrinsically controls eosinophil accumulation in the setting of allergic airway inflammation. | Nobs, SP., et al. 2019. J Allergy Clin Immunol. 143: 1513-1524.e2. PMID: 30244025
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GM-CSF Antibody (H-3) | sc-398649 | 200 µg/ml | $322.00 | |||
GM-CSF Antibody (H-3): m-IgGκ BP-HRP Bundle | sc-551784 | 200 µg Ab; 40 µg BP | $361.00 | |||
GM-CSF (H-3) Neutralizing Peptide | sc-398649 P | 100 µg/0.5 ml | $69.00 |