Glycogenin-2 Antibody (3L10): sc-134346
- Glycogenin-2 Antibody (3L10) is a mouse monoclonal IgG2a κ Glycogenin-2 antibody provided at 100 µg/ml
- raised against recombinant Glycogenin-2 protein of human origin
- recommended for detection of Glycogenin-2 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Glycogenin-2 Antibody (3L10). This work is in progress.
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Glycogenin-2 Antibody (3L10) is a mouse monoclonal IgG2a kappa light chain antibody that detects Glycogenin-2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Glycogenin-2 antibody (3L10) is available as a non-conjugated monoclonal isotype antibody. Glycogenin-2, also known as GYG2 or GN2, is a 501 amino acid protein that belongs to the glycogenin family and exists as six alternatively spliced isoforms, designated alpha, beta, gamma, delta, epsilon, and zeta. Glycogenin-2 is primarily expressed in heart, pancreas, and liver, where Glycogenin-2 plays a crucial role as a homodimer that utilizes divalent metal ions as cofactors to catalyze self-glucosylation. This process generates an oligosaccharide primer that serves as a substrate for glycogen synthase, thereby regulating glycogen accumulation within cells. Glycogenin-2 maintains energy homeostasis, particularly in tissues with high energy demands, such as heart and skeletal muscle. The gene encoding Glycogenin-2 is located on human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes, playing a significant role in sex determination and various genetic conditions associated with sex chromosome abnormalities, including Turner′s syndrome and Duchenne muscular dystrophy.
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Glycogenin-2 Antibody (3L10) References:
- Novel aspects of the regulation of glycogen storage. | Roach, PJ., et al. 1998. J Basic Clin Physiol Pharmacol. 9: 139-51. PMID: 10212831
- Structure and chromosomal localization of the human glycogenin-2 gene GYG2. | Zhai, L., et al. 2000. Gene. 242: 229-35. PMID: 10721716
- Do rodents have a gene encoding glycogenin-2, the liver isoform of the self-glucosylating initiator of glycogen synthesis? | Zhai, L., et al. 2001. IUBMB Life. 51: 87-91. PMID: 11463169
- Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin. | Gibbons, BJ., et al. 2002. J Mol Biol. 319: 463-77. PMID: 12051921
- Hepatic and neuromuscular forms of glycogen storage disease type IV caused by mutations in the same glycogen-branching enzyme gene. | Bao, Y., et al. 1996. J Clin Invest. 97: 941-8. PMID: 8613547
- Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis. | Mu, J., et al. 1997. J Biol Chem. 272: 27589-97. PMID: 9346895
- Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism. | Mu, J. and Roach, PJ. 1998. J Biol Chem. 273: 34850-6. PMID: 9857012
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Glycogenin-2 Antibody (3L10) | sc-134346 | 100 µg/ml | $339.00 |