Garcinol CAS: 78824-30-3
MF: C38H50O6
MW: 602.80
A potent p300 and PCAF histone acetyltransferase inhibitor.

Garcinol (CAS 78824-30-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 190ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
同義語 Camboginol
アプリケーション: A potent p300 and PCAF histone acetyltransferase inhibitor
CAS 番号: 78824-30-3
Purity: ≥95%
Molecular Weight: 602.80
Molecular Formula: C38H50O6
* Refer to Certificate of Analysis for lot specific data (including water content).
この製品のレビューを提出し、15 CruzCreditsを受け取ります

Garcinol (camboginol) is a polyisoprenylated benzophenone derivative from the rind of Garcinia indica fruit and is a potent inhibitor of histone acetyltransferases p300 (IC50 ~ 7 μM) and PCAF (IC50 ~ 5 μM) in vitro. P300, also known as E1A binding protein p300, regulates cell growth and division via interactions with numerous transcription factors, and the p53 associated trancriptional coactivator PCAF (P300/CBP-associated factor) plays a direct role in transcriptional regulation. Reports show that garcinol represses the p300-mediated acetylation of p53 and promotes apoptosis through caspase-3 activation. Additionally, this compound predominantly down-regulates global gene expression in HeLa cells. Researchers found that garcinol exhibits dose-dependent cancer cell-specific growth inhibition in ER-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells. Additional research shows that garcinol exhibits anti-carcinogenic and antiiinflammatory properties through selective suppression of prostaglandin E2 synthesis and 5-lipoxygenase product formation.


1. Matsumoto, Kenji., et al., 2003. Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines. Biological & pharmaceutical bulletin. 26(4): 569-71. PMID: 12673047
2. Balasubramanyam, Karanam., et al., 2004. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. The Journal of biological chemistry. 279(32): 33716-26. PMID: 15155757
3. Mantelingu, K., et al., 2007. Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chemistry & biology. 14(6): 645-57. PMID: 17584612
4. Koeberle, Andreas., et al., 2009. Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol. Biochemical pharmacology. 77(9): 1513-21. PMID: 19426689
5. Ahmad, Aamir., et al., 2010. Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells. Journal of cellular biochemistry. 109(6): 1134-41. PMID: 20108249
6. Chen, Ching-Shyang., et al., 2011. Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins. Breast cancer research and treatment. 125(1): 73-87. PMID: 20229177

Physical State :
Solubility :
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), and DMF (25 mg/ml). Insoluble in water.
保存方法 :
Store at -20° C
Melting Point :
72° C
Boiling Point :
~710.8° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.56
IC50 :
histone acetyltransferases (HATs) p300: IC50 = 7 µM; PCAF: IC50 = 5 µM
Ki Data :
Histone acetyltransferase p300: Ki= 4900 nM
pK Values :
pKa: 4.5
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
PubChem CID :
MDL Number :

Download SDS (MSDS)


Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Garcinol  参考文献

See how others have used Garcinol. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 29174768  Ghosh, TK. et al. 2018. J. Mol. Cell. Cardiol. 114: 185-198.

PMID: # 29414668  Huang, WC.|Kuo, KT.|Adebayo, BO.|Wang, CH.|Chen, YJ.|Jin, K.|Tsai, TH.|Yeh, CT.| et al. 2018. J. Nutr. Biochem. 54: 140-150.

PMID: # 29740418  Simpson, S. et al. 2018. Front Microbiol. 9: 788.

PMID: # 25538147  Yao, XH. et al. 2014. Physiological reports. 2:

PMID: # 23644046  Du, T. et al. 2013. Experimental and molecular pathology. 95: 38-45.

PMID: # 30377593  Habibi, A.|Soleimani, M.|Atashi, A.|AkhavanRahnama, M.|Anbarlou, A.|Ajami, M.|Ajami, M.| et al. Avicenna J Phytomed. 8: 350-357.

Citations 1 to 6 of 6 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 148ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 17ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

サンタクルーズバイオテクノロジーは生物医学研究市場向けの製品の開発における世界的リーダです。 下記フリー ダイヤルにお電話ください: 1-800-457-3801。Copyright © 2007-2020 Santa Cruz Biotechnology, Inc.全著作権所有。"Santa Cruz Biotechnology"、 及びSanta Cruz Biotechnology, Inc. ロゴ、 "Santa Cruz Animal Health"、 "San Juan Ranch"、 "Supplement of Champions"、 San Juan Ranch ロゴ、 "Ultracruz"、 "Chemcruz"、 "Immunocruz"、 "Exactacruz"、 と "EZ Touch"はサンタクルーズバイオテクノロジーの登録商標です。 商標はそれぞれの所有者に帰属します。