FOXM1 Antibody (D-4): sc-166709
- FOXM1 Antibody (D-4) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 502-801 mapping at the C-terminus of FOXM1 of human origin
- recommended for detection of all isoforms of FOXM1 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-166709 X, 200 µg/0.1 ml)
- See FOXM1 (G-5): sc-376471 for FOXM1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FOXM1 Antibody (D-4). This work is in progress.
FOXM1 Antibody (D-4) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect FOXM1, a crucial transcription factor involved in the regulation of cell proliferation, cell cycle progression, and DNA damage repair. anti-FOXM1 antibody (D-4) is raised against amino acids 502-801, targeting the C-terminus of human FOXM1, and demonstrates robust reactivity across multiple species including mouse, rat, and human. Validated for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA), FOXM1 (D-4) antibody is an essential tool for researchers studying cellular growth, cancer biology, and related fields. Forkhead box M1 (FOXM1), also called FKHL16, HFH11, INS-1, and PIG29, plays a pivotal role in activating the transcription of key cell cycle regulators like cyclin B1, cyclin D1, and Cdc25B, which are vital for the transition from G1 to S phase and for mitotic entry. FOXM1 expression is predominantly observed in proliferating cells, including those in the thymus, testis, small intestine, and colon, and is tightly regulated to ensure proper cellular proliferation and tissue regeneration. Dysregulation of FOXM1 is associated with various cancers, as overexpression can lead to uncontrolled cell division and tumor progression. Additionally, alternative splicing of FOXM1 results in isoforms such as FOXM1A and FOXM1B, which have distinct roles in protein stability and function, impacting processes like cellular aging and hepatocyte DNA replication. FOXM1 monoclonal antibody (D-4) enables researchers to effectively investigate the intricate mechanisms of FOXM1 in both normal and pathological states, facilitating advancements in understanding and potentially targeting proliferative diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FOXM1 Antibody (D-4) | sc-166709 | 200 µg/ml | $322.00 | |||
FOXM1 Antibody (D-4) X | sc-166709 X | 200 µg/0.1 ml | $322.00 |