Fidaxomicin CAS: 873857-62-6
MF: C52H74Cl2O18
MW: 1058.04
A macrocyclic antibiotic.

Fidaxomicin (CAS 873857-62-6)

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別名: Dificid, Dificlir
アプリケーション: Fidaxomicin is a macrocyclic antibiotic
CAS 番号: 873857-62-6
Purity: ≥98%
Molecular Weight: 1058.04
Molecular Formula: C52H74Cl2O18
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* Refer to Certificate of Analysis for lot specific data (including water content).

Fidaxomicin is a recently approved antibiotic with a confusing history dating back to its original isolation in 1975. Fidaxomicin is the major analogue of a family of macrocyclic lactones isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic that works by inhibiting bacterial RNA polymerase and demonstrates excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora.

Physical State :
Solid
Derived From :
Dactylosporum aurantiacum
Solubility :
Soluble in ethanol, methanol, DMF, DMSO, and Limited water solubility.
保存方法 :
Store at -20° C
Boiling Point :
~1046.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
46174142
SMILES :
CC[[email protected]]1/C=C(\\[[email protected]](C/C=C/C=C(/C(=O)O[[email protected]@H](C/C=C(/C=C(/[[email protected]@H]1O[[email protected]]2[[email protected]]([[email protected]]([[email protected]@H](C(O2)(C)C)OC(=O)C(C)C)O)O)\\C)\\C)[[email protected]@H](C)O)\\CO[[email protected]]3[[email protected]]([[email protected]]([[email protected]@H]([[email protected]](O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)/C

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Fidaxomicin (CAS 873857-62-6)  参考文献

See how others have used Fidaxomicin (CAS 873857-62-6). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 30052178  Skinner, K. et al. 2018. J. Med. Microbiol. 67: 1402-1409.

PMID: # 28533232  Corbett, D. et al. 2017. Antimicrob. Agents Chemother.

PMID: # 25652750  Corbett, D. et al. 2015. J. Antimicrob. Chemother. 70: 1751-6.

Citations 1 to 3 of 3 total
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