m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for Eps8 Antibody (F-8) for WB applications. This reagent is now offered in a bundle with Eps8 Antibody (F-8) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Eps8 Antibody (F-8) is a high quality monoclonal Eps8 antibody (also designated Eps8 antibody) suitable for the detection of the Eps8 protein of mouse, rat and human origin. Eps8 Antibody (F-8) is available as both the non-conjugated anti-Eps8 antibody form, as well as multiple conjugated forms of anti-Eps8 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation. Miscues in RTK signaling pathways can result in cellular transformation and ultimately in cancer. Two novel EGF receptor substrates designated EGF-receptor pathway substrates 8 and 15, or Eps8 and Eps15, have been described. Eps8 and Eps15 become tyrosine phosphorylated subsequent to EGF stimulation. Overexpression of Eps15 in NIH/3T3 cells causes cellular transformation, implying involvement in the regulation of cell proliferation. Eps15 is capable of binding the amino-terminal portion of Crk via a conserved proline-rich domain, characteristic of all Crk binding proteins. Over-expression of Eps8 in both fibroblasts and hematopoietic cells results in an increased mitogenic response to EGF. Eps8 has been shown to associate with the EGF receptor despite its lack of a functional SH2 domain. Further characterization suggests the protein has both a PH domain and a SH3 domain, the functional significance of which are not yet known.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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