DYDC2抗体(9H8): sc-134323

3.0(1)

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データシート

- DYDC2抗体 9H8はマウスモノクローナルIgG_2aDYDC2 抗体です。100 µg/mlで提供
- raised against recombinant DYDC2 protein of human origin
- human由来のDYDC2 WB, IP と ELISAでの検出にはお勧めします
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DYDC2 Antibody (9H8). This work is in progress.

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DYDC抗体
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DYDC2 Antibody (9H8) - Western Blotting - Image 64919

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DYDC2 Antibody (9H8) is an IgG_2a κ mouse monoclonal DYDC2 antibody (also designated DYDC2 antibody) that detects the DYDC2 protein of human origin by WB, IP and ELISA. DYDC2 Antibody (9H8) is available as the non-conjugated anti-DYDC2 antibody. The Dumpy-30 (DPY-30) protein was first described in C. elegans, in which it is involved in dosage compensation of sex chromosomes. Conserved from yeast to humans, the DPY-30 family is involved in gene expression and chromatin modifications, specifically histone methylation. DPY-30 and closely related proteins contain a short motif that is related to the dimerization motif in the regulatory subunit of protein kinase A (PKA), which consists of two α-helices that form a four-helix bundle during dimerization. As a member of the DPY-30 family, DYDC2 (DPY30 domain-containing protein 2) is a 177 amino acid protein that may inhibit MTF-1-dependent reporter gene expression. Knockdown of DYDC2 mRNA results in male sterility by impairing sperm motility.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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References:

The Caenorhabditis elegans dosage compensation machinery is recruited to X chromosome DNA attached to an autosome. | Lieb, JD., et al. 2000. Genetics. 156: 1603-21. PMID: 11102361
Characterization and crystallization of human DPY-30-like protein, an essential component of dosage compensation complex. | Dong, X., et al. 2005. Biochim Biophys Acta. 1753: 257-62. PMID: 16260194
Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3. | Kuhl, A., et al. 2008. Eur J Hum Genet. 16: 367-73. PMID: 18197198
Dumpy-30 family members as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. | Vardanyan, A., et al. 2008. BMC Dev Biol. 8: 68. PMID: 18588663
Crystal structure of the C-terminal domain of human DPY-30-like protein: A component of the histone methyltransferase complex. | Wang, X., et al. 2009. J Mol Biol. 390: 530-7. PMID: 19481096
Interaction of SH3P13 and DYDC1 protein: a germ cell component that regulates acrosome biogenesis during spermiogenesis. | Li, S., et al. 2009. Eur J Cell Biol. 88: 509-20. PMID: 19545932
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. | Patel, A., et al. 2009. J Biol Chem. 284: 24242-56. PMID: 19556245
DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation. | Hsu, DR., et al. 1995. Development. 121: 3323-34. PMID: 7588066
The dpy-30 gene encodes an essential component of the Caenorhabditis elegans dosage compensation machinery. | Hsu, DR. and Meyer, BJ. 1994. Genetics. 137: 999-1018. PMID: 7982580

動物種	遺伝子名	Gene ID	Chromosome Location	Isoform (mRNA) Accession Number	Protein Accession Number	OMIM™ Number
Human	DYDC2	Entrez Gene ID: 84332	10q23.1	XM_011540267, XM_011540268, XM_011540270, NM_001270041, NM_001270042, NM_032372	UniProt ID: Q96IM9	n/a

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DYDC2抗体(9H8): sc-134323

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