DENR Antibody (NQ-B8): sc-134315

DENR Antibody (NQ-B8) is a mouse monoclonal IgG2a antibody that detects DENR in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). DENR, also known as density-regulated protein or smooth muscle cell-associated protein 3 (SMAP-3), is a 198 amino acid protein whose expression is notably elevated in high-density cell environments, indicating a role in cellular responses to density changes. DENR is predominantly located in skeletal and cardiac muscle tissues, where DENR plays a crucial role in regulating protein synthesis and cellular growth. DENR′s presence in these tissues suggests involvement in muscle development and function, as well as potential implications in diseases related to muscle degeneration. Additionally, DENR contains a SUI1 domain, which is homologous to the budding yeast protein SUI1, a key translation-initiation factor that ensures the ribosome accurately locates the translation start site. This structural feature underscores DENR′s importance in the regulation of translation, making DENR a significant player in cellular metabolism and growth control. Anti-DENR antibody (NQ-B8) is an essential tool for researchers investigating the molecular mechanisms underlying muscle biology and density-dependent cellular processes.

The preferred DENR antibody is DENR Antibody (22): sc-136254.