DCEBIO (CAS 60563-36-2)
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DCEBIO is a chemical that functions as an activator of calcium-activated potassium channels. It modulates the activity of these channels by increasing their open probability, leading to the efflux of potassium ions from the cell. This chemical′s mode of action involves binding to the calcium-activated potassium channels and inducing conformational changes that promote channel opening. By doing so, DCEBIO plays a role in regulating membrane potential and cellular excitability. Its interaction at the molecular level affects the flow of potassium ions across the cell membrane, influencing various physiological processes. In a research and development setting, this chemical′s function as a potassium channel activator is of interest for studying the role of these channels in cellular signaling and ion homeostasis. Its mode of action provides insights into the mechanisms underlying potassium channel function and its impact on cellular physiology.
DCEBIO (CAS 60563-36-2) References
- Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. | Singh, S., et al. 2001. J Pharmacol Exp Ther. 296: 600-11. PMID: 11160649
- DCEBIO stimulates Cl- secretion in the mouse jejunum. | Hamilton, KL. and Kiessling, M. 2006. Am J Physiol Cell Physiol. 290: C152-64. PMID: 16135545
- Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons. | Pedarzani, P., et al. 2005. J Biol Chem. 280: 41404-11. PMID: 16239218
- Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells. | Morimura, K., et al. 2006. J Pharmacol Sci. 100: 237-41. PMID: 16518073
- DCEBIO-mediated dilations are attenuated in the female rat middle cerebral artery. | Sokoya, EM., et al. 2007. J Vasc Res. 44: 169-74. PMID: 17308435
- Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation. | Sheng, JZ., et al. 2009. FASEB J. 23: 1138-45. PMID: 19074509
- Ictal activity induced by group I metabotropic glutamate receptor activation and loss of afterhyperpolarizations. | Pan, YZ., et al. 2010. Neuropharmacology. 59: 86-92. PMID: 20385148
- Intermediate conductance Ca2+-activated K+ channels modulate human placental trophoblast syncytialization. | Díaz, P., et al. 2014. PLoS One. 9: e90961. PMID: 24595308
- Modulating fear extinction memory by manipulating SK potassium channels in the infralimbic cortex. | Criado-Marrero, M., et al. 2014. Front Behav Neurosci. 8: 96. PMID: 24715857
- Effects of ibandronate sodium, a nitrogen-containing bisphosphonate, on intermediate-conductance calcium-activated potassium channels in osteoclast precursor cells (RAW 264.7). | Wu, SN., et al. 2015. J Membr Biol. 248: 103-15. PMID: 25362532
- DCEBIO facilitates myogenic differentiation via intermediate conductance Ca2+ activated K+ channel activation in C2C12 myoblasts. | Tanaka, S., et al. 2017. J Pharmacol Sci. 133: 276-279. PMID: 28302447
- [A Cellular Pharmacological Approach to the Development of Drugs to Treat Muscle Wasting]. | Sakamoto, K. 2018. Yakugaku Zasshi. 138: 1271-1275. PMID: 30270271
- Opening of Intermediate Conductance Ca2+-Activated K+ Channels in C2C12 Skeletal Muscle Cells Increases the Myotube Diameter via the Akt/Mammalian Target of Rapamycin Pathway. | Iseki, Y., et al. 2021. J Pharmacol Exp Ther. 376: 454-462. PMID: 33376149
- Involvement of small-conductance Ca2+-activated K+ (SKCa2) channels in spontaneous Ca2+ oscillations in rat pinealocytes. | Ando, S., et al. 2022. Biochem Biophys Res Commun. 615: 157-162. PMID: 35643055
- KCa3.1 potentiation stimulates Cl- secretion in F508del and G551D CFTR-corrected primary human bronchial epithelial cells. | Devor, DC., et al. 2022. Am J Physiol Cell Physiol. 323: C1215-C1230. PMID: 36062876
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DCEBIO, 10 mg | sc-203561 | 10 mg | $107.00 | |||
DCEBIO, 50 mg | sc-203561A | 50 mg | $417.00 |