DARPP-32 Antibody (15): sc-135877

DARPP-32 Antibody (15) is a mouse monoclonal IgG1 light chain antibody that detects DARPP-32 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). DARPP-32, or dopamine and adenosine 3′,5′-monophosphate-regulated phosphoprotein, plays a crucial role in dopaminergic signaling pathways, which are vital for various brain functions, including motor control, cognition, and emotional regulation. DARPP-32 is predominantly located in the cytoplasm of neurons that receive dopaminergic input, where DARPP-32 acts as a key integrator of dopamine signaling. Proper localization of DARPP-32 is essential because DARPP-32 allows for precise modulation of downstream signaling pathways in response to dopamine, influencing neuronal excitability and synaptic plasticity. The phosphorylation state of DARPP-32 can determine DARPP-32′s function as a potent inhibitor of protein phosphatase 1 (PP-1), thereby regulating the balance between phosphorylation and dephosphorylation of various target proteins involved in neurotransmission. DARPP-32′s ability to interact with multiple signaling pathways highlights DARPP-32′s significance in understanding the molecular mechanisms underlying neurological disorders such as schizophrenia and Parkinson′s disease, making anti-DARPP-32 antibody (15) an invaluable tool for researchers studying these complex conditions.

The preferred DARPP-32 antibody is DARPP-32 Antibody (H-3): sc-271111.