D-myo-Inositol-1,3,4-triphosphate sodium salt MF: C6H12O15P3•3Na
MW: 486.04
An inhibitor of Ins(3,4,5,6)-P4 kinase activity.

D-myo-Inositol-1,3,4-triphosphate sodium salt

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別名: 1,3,4-IP3 (sodium salt); Ins(1,3,4)-P3 (sodium salt)
アプリケーション: D-myo-Inositol-1,3,4-triphosphate sodium salt is an inhibitor of Ins(3,4,5,6)-P4 kinase activity
Purity: >98%
Molecular Weight: 486.04
Molecular Formula: C6H12O15P33Na
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* Refer to Certificate of Analysis for lot specific data (including water content).

D-myo-Inositol-1,3,4-triphosphate sodium salt is one of many inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels. The levels of Ins(1,3,4)-P3 are regulated by the levels of cytosolic free calcium. The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs. This leads to increase in the cytosolic concentration of free calcium.


参考文献

1. Majerus, P.W. 1992. Annu. Rev. Biochem. 61: 225-250. PMID: 1323235
2. Berridge, M.J. 1993. Nature. 361: 315-325. PMID: 8381210
3 Yang, X., et al. 1999. J Biol Chem 274: 18973-18980.PMID: 10383396
4 Lew, P.D., et al. 1986. J Biol Chem. 261: 13121-13127. PMID: 3489712 5 Yoshida, Y. and Imai, S. 1997. Jpn. J. Pharmacol. 74: 125-137. PMID: 9243320

Appearance :
Lyophilized powder
Physical State :
Solid
保存方法 :
Store at -20° C
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
53394553
SMILES :
[P](O[[email protected]@H]1[[email protected]@H](O[P](O)([O-])=O)[[email protected]](O)[[email protected]@H](O)[[email protected]](O[P](O)([O-])=O)[[email protected]@H]1O)(O)([O-])=O.[Na+].[Na+].[Na+]

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