D-myo-Inositol-1,2,5,6-tetraphosphate, sodium salt MF: C6H12O18P4•4Na
MW: 588.00
A small, soluble second messenger in the transmission of cellular signals.

D-myo-Inositol-1,2,5,6-tetraphosphate, sodium salt

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別名: Ins(1,2,5,6)P4 (sodium salt); 1,2,5,6-IP4 (sodium salt)
アプリケーション: D-myo-Inositol-1,2,5,6-tetraphosphate, sodium salt is a small, soluble second messenger in the transmission of cellular signals
Purity: ≥98%
Molecular Weight: 588.00
Molecular Formula: C6H12O18P44Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

D-myo-Inositol-1,2,5,6-tetraphosphate, sodium salt is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals.1,2,3. Ins(1,2,5,6)P4 binds to the murine Grp-1 PH domain with a Kd(apparent).4 It binds to rat heart membranes and significantly decreases heart rate in a pithed rat model.


参考文献

1 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993). 2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992). 3 Shears, S.B. The versatility of inositol phosphates as cellular signals. Biochim Biophys Acta 1436 49-67 (1998). 4 Kavran, J.M., Klein, D.E., Lee, A., et al. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J Biol Chem 273(46) 30497-30508 (1998). 5 Sun, X.X., Edvinsson, L., Yoo, H., et al. Effects of some novel D-myo-inositol-phosphate derivatives on binding and sympathetic transmission. J Cardiovasc Pharmacol 25 696-704 (1995).

Appearance :
Lyophilized powder
Physical State :
Solid
保存方法 :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
57347477
SMILES :
[[email protected]@H]1([[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]]([[email protected]]1O[P](O)(=O)[O-])O)O)O[P]([O-])(=O)O)O[P](=O)(O)[O-])O[P](=O)([O-])O.[Na+].[Na+].[Na+].[Na+]

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