D-Amino Acid Oxidase 抑制剤 CAS: 39793-31-2
MF: C7H5NO2S
MW: 167.2
A thienopyrrole compound that inhibits cellular activity in CHO cells.

D-Amino Acid Oxidase 抑制剤 (CAS 39793-31-2)

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別名: 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid
アプリケーション: D-Amino Acid Oxidase Inhibitor is a thienopyrrole compound that inhibits cellular activity in CHO cells
CAS 番号: 39793-31-2
Purity: ≥97%
Molecular Weight: 167.2
Molecular Formula: C7H5NO2S
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* Refer to Certificate of Analysis for lot specific data (including water content).

D-Amino Acid Oxidase Inhibitor is a cell-permeable thienopyrrole compound that potently inhibits cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively). Exhibits no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.


参考文献

1. Smith, S.M., et al. 2009. J. Pharmacol. Exp. Ther. 328: 921-930. PMID: 19088300
2. Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett. 18: 3386-3391. PMID: 18455394

Physical State :
Solid
Solubility :
Soluble in DMSO, and 5% NaOH.
保存方法 :
Store at 4° C
Melting Point :
201-205° C
Boiling Point :
437.41° C at 760 mmHg (Predicted)
Density :
1.61 g/cm3 (Predicted)
Refractive Index :
n20D 1.79 (Predicted)
IC50 :
DAO: IC50 = 145 nM (human); DAO: IC50 = 114 nM (rat); D-aspartate oxidase: IC50 = >5 µM; P450 enzymes CYP3A4/2D6/3C9: IC50 = >10 µM
pK Values :
pKa: 4.36 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
MDL Number :
MFCD07368542
SMILES :
CCOC(=O)C1=CC2=C(N1)C=CS2

Download SDS (MSDS)

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