connexin 32 Antibody (HAM8): sc-21794
- connexin 32 Antibody (HAM8) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 229-239, within the cytoplasmic region near the C-terminus
- recommended for detection of connexin 32 of mouse, rat and human origin by WB, IP and IF
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for connexin 32 Antibody (HAM8) for WB applications. This reagent is now offered in a bundle with connexin 32 Antibody (HAM8) (see ordering information below).
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Connexin 32 Antibody (HAM8) is a mouse monoclonal IgG1 light chain antibody that detects connexin 32 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Connexin 32 plays a crucial role in the formation of gap junctions, which are essential for intercellular communication, allowing the passage of ions and small molecules between adjacent cells. Connexin 32 is predominantly located in the cell membrane, where connexin 32 forms hexameric complexes known as connexons, facilitating the direct transfer of signaling molecules and nutrients. Proper functioning of connexin 32 is vital for maintaining tissue homeostasis and coordinating cellular responses, particularly in the nervous system. Disruptions in connexin 32 expression or function can lead to severe pathological conditions, such as Charcot-Marie-Tooth disease, highlighting connexin 32′s importance in peripheral nerve function and myelination. Anti-connexin 32 antibody (HAM8) enables researchers to investigate the expression levels and localization of this critical protein, furthering our understanding of connexin 32′s role in health and disease.
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connexin 32 Antibody (HAM8) References:
- Double expressions of connexin 43 and 32 in human periodontal ligament fibroblasts. | Yamaoka, Y., et al. 2000. Tissue Cell. 32: 328-35. PMID: 11145016
- Localization of connexin 32 in spontaneous liver lesions of mice. | Igarashi, I., et al. 2016. J Vet Med Sci. 78: 113-6. PMID: 26268664
- Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis. | Kato, H., et al. 2016. Oncotarget. 7: 2009-21. PMID: 26655499
- Connexin 32-mediated cell-cell communication is essential for hepatic differentiation from human embryonic stem cells. | Qin, J., et al. 2016. Sci Rep. 6: 37388. PMID: 27874032
- Connexin 32 affects doxorubicin resistance in hepatocellular carcinoma cells mediated by Src/FAK signaling pathway. | Yu, M., et al. 2017. Biomed Pharmacother. 95: 1844-1852. PMID: 28968929
- Effects of Connexin 32-Mediated Lung Inflammation Resolution During Liver Ischemia Reperfusion. | Zhang, Z., et al. 2020. Dig Dis Sci. 65: 2914-2924. PMID: 31900713
- Author Correction: Connexin 32-mediated cell-cell communication is essential for hepatic differentiation from human embryonic stem cells. | Qin, J., et al. 2020. Sci Rep. 10: 6165. PMID: 32249799
- Connexin 32 induces pro-tumorigenic features in MCF10A normal breast cells and MDA-MB-231 metastatic breast cancer cells. | Adak, A., et al. 2020. Biochim Biophys Acta Mol Cell Res. 1867: 118851. PMID: 32918981
- Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels. | Qi, C., et al. 2023. Sci Adv. 9: eadh4890. PMID: 37647412
- Role of connexin 32 in the directional differentiation of induced pluripotent stem cells into hepatocytes. | Xu, Y., et al. 2024. Int J Med Sci. 21: 508-518. PMID: 38250613
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
connexin 32 Antibody (HAM8) | sc-21794 | 200 µg/ml | $322.00 | |||
connexin 32 Antibody (HAM8): m-IgG Fc BP-HRP Bundle | sc-538911 | 200 µg Ab; 10 µg BP | $361.00 |