Cks2 Antibody (3B3): sc-81833
- Cks2 Antibody (3B3) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant Cks2 of human origin
- recommended for detection of Cks2 of mouse, rat and human origin by IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Cks2 Antibody (3B3). This work is in progress.
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Cks2 Antibody (3B3) is a mouse monoclonal IgG2b antibody that detects Cks2 in mouse, rat, and human samples through applications such as immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA). Cks2, or Cyclin-dependent kinases regulatory subunit 2, is a crucial 79 amino acid protein that plays a significant role in the regulation of the cell cycle by binding to the catalytic subunit of cyclin-dependent kinases, particularly within the Cdc2 p34-cyclin B complex. This complex, also known as M phase promoting factor or MPF, is essential for the transition from the G2 phase to mitosis, making Cks2 vital for proper cell division. The ability of Cks2 to form a homohexamer allows binding of up to six subunits, enhancing regulatory capacity and ensuring correct cell cycle progression. Disruption of Cks2 function can lead to failure in the metaphase/anaphase transition during meiosis, highlighting its importance in maintaining genomic stability. Anti-Cks2 antibody (3B3) serves as an invaluable tool for researchers studying cell cycle dynamics and molecular mechanisms underlying cell division.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cks2 Antibody (3B3) References:
- Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73. | Rother, K., et al. 2007. FEBS Lett. 581: 1166-72. PMID: 17336302
- Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins. | Liberal, V., et al. 2012. Proc Natl Acad Sci U S A. 109: 2754-9. PMID: 21697511
- CKS2 Promotes the Growth in Non-Small-Cell Lung Cancer by Downregulating Cyclin-Dependent Kinase Inhibitor. | Wan, Z., et al. 2022. Pathobiology. 89: 13-22. PMID: 34333494
- Clinicopathological value of the upregulation of cyclin-dependent kinases regulatory subunit 2 in osteosarcoma. | Mo, C., et al. 2022. BMC Med Genomics. 15: 81. PMID: 35410253
- Expression Profile and Molecular Basis of Cyclin-Dependent Kinases Regulatory Subunit 2 in Endometrial Carcinoma Detected by Diversified Methods. | Gao, L., et al. 2022. Pathol Oncol Res. 28: 1610307. PMID: 35693634
- Cyclin-Dependent Kinase Subunit 2 (CKS2) as a Prognostic Marker for Stages I-III Invasive Non-Mucinous Lung Adenocarcinoma and Its Role in Affecting Drug Sensitivity. | Feng, J., et al. 2022. Cells. 11: PMID: 36010686
- E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma. | Chen, M., et al. 2022. Cell Death Dis. 13: 784. PMID: 36096885
- Cyclin-dependent kinase subunit2 (CKS2) promotes malignant phenotypes and epithelial-mesenchymal transition-like process in glioma by activating TGFβ/SMAD signaling. | Feng, F., et al. 2023. Cancer Med. 12: 5889-5907. PMID: 36284444
- Prognostic significance of cyclin-dependent kinase subunit 2 (CKS2) in malignant tumours: a meta-analysis and bioinformatic analysis. | Zhang, Y., et al. 2024. BMJ Open. 14: e073887. PMID: 38296306
- Biological functions and therapeutic potential of CKS2 in human cancer. | Lai, Y. and Lin, Y. 2024. Front Oncol. 14: 1424569. PMID: 39188686
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cks2 Antibody (3B3) | sc-81833 | 100 µg/ml | $339.00 |