Chromomycin A3 CAS: 7059-24-7
MF: C57H82O26
MW: 1183.25
A G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye.

Chromomycin A3 (CAS 7059-24-7)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 153ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
5
1
4
0
3
0
2
0
1
0
アプリケーション: A G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye
CAS 番号: 7059-24-7
Purity: ≥97%
Molecular Weight: 1183.25
Molecular Formula: C57H82O26
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
この製品のレビューを提出し、15 CruzCreditsを受け取ります

Chromomycin A3, a fluorescent DNA stain and antibiotic, has been reported to strongly inhibit zinc-dependent transcriptional activity of sheep Metallothionein 1A promoter in reporter gene assays of transfected cells. This compound has also been shown to be a potent inhibitor of neuronal apoptosis induced by glutathione depletion-induced oxidative stress and DNA-damaging agent Camptothecin (sc-200871). Mechanistic studies suggest that Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate "G-C" box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting transcription, Chromomycin A3 and its structural analogs can inhibit protein biosynthesis.


参考文献

1. Jeon, C.J., et al. 1993. J. Histochem. Cytochem. 41: 1651-1658. PMID: 8409373
2. Wong, S.S., et al. 1994. Biochem. Pharmacol. 47: 827-837. PMID: 7510966
3. Chatterjee, S., et al. 2001. Ann. Neurol. 49: 345-354. PMID: 11261509
4. Mir, M.A., et al. 2003. Bioorg. Med. Chem. 11: 2791-2801. PMID: 12788353
5. Hoyos, P., et al. 2010. Acc. Chem. Res. 43: 288-299. PMID: 19908854

Physical State :
Solid
Derived From :
Streptomyces griseus
Solubility :
Soluble in ethanol, DMSO, and ethyl acetate (10 mg/ml).
保存方法 :
Store at -20° C
Melting Point :
185° C (dec.)
Refractive Index :
n20D 1.62
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
GB7875000
PubChem CID :
5179132
Merck Index :
14: 2238
MDL Number :
MFCD00043151
EC Number :
230-348-0
SMILES :
CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O

Download SDS (MSDS)

分析表

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 138ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 12ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

サンタクルーズバイオテクノロジーは生物医学研究市場向けの製品の開発における世界的リーダです。 下記フリー ダイヤルにお電話ください: 1-800-457-3801。Copyright © 2007-2020 Santa Cruz Biotechnology, Inc.全著作権所有。"Santa Cruz Biotechnology"、 及びSanta Cruz Biotechnology, Inc. ロゴ、 "Santa Cruz Animal Health"、 "San Juan Ranch"、 "Supplement of Champions"、 San Juan Ranch ロゴ、 "Ultracruz"、 "Chemcruz"、 "Immunocruz"、 "Exactacruz"、 と "EZ Touch"はサンタクルーズバイオテクノロジーの登録商標です。 商標はそれぞれの所有者に帰属します。