β-defensin 2 Antibody (B 235-I): sc-59494
- β-defensin 2 Antibody (B 235-I) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against amino acids 4-41 of β-defensin 2 of human origin
- recommended for detection of synthetic β-defensin 2 of human origin by ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for β-defensin 2 Antibody (B 235-I). This work is in progress.
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β-defensin 2 Antibody (B 235-I) is a mouse monoclonal IgG1 antibody that detects β-defensin 2 in humans through enzyme-linked immunosorbent assay (ELISA). β-defensin 2 monoclonal antibody (B 235-I) recognizes a crucial antimicrobial peptide that plays a significant role in the innate immune response, particularly in mucosal surfaces where β-defensin 2 helps protect against a wide range of pathogens. β-defensin 2 is primarily produced in mucosal epithelia and neutrophils, and expression is tightly regulated by inflammatory signals, making β-defensin 2 a key player in the body′s defense mechanisms during infection. β-defensin 2 (B 235-I) antibody targets the first member of the β-defensin family that can be locally induced by inflammation, highlighting β-defensin 2′s importance in the immediate immune response. β-defensin 2′s ability to form a stable structure, characterized by a conserved cysteine framework, is essential for antimicrobial activity, as this allows for the formation of a functional three-dimensional conformation that can effectively disrupt microbial membranes. β-defensin 2 (B 235-I) monoclonal antibody serves as an invaluable tool for researchers studying the dynamics of immune responses and the role of antimicrobial peptides in health and disease.
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β-defensin 2 Antibody (B 235-I) References:
- β-Defensin 2 is a responsive biomarker of IL-17A-driven skin pathology in patients with psoriasis. | Kolbinger, F., et al. 2017. J Allergy Clin Immunol. 139: 923-932.e8. PMID: 27502297
- β-Defensin-2 is overexpressed in human vocal cord polyps. | Gu, J. and Huang, Y. 2017. Eur Arch Otorhinolaryngol. 274: 901-907. PMID: 27586391
- Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response. | Cieślik, M., et al. 2021. Cells. 10: PMID: 34831214
- Human Beta Defensin 2 Ameliorated Alcohol-Associated Liver Disease in Mice. | Warner, JB., et al. 2021. Front Physiol. 12: 812882. PMID: 35153819
- Human β-Defensin 2 (HBD-2) Displays Oncolytic Activity but Does Not Affect Tumour Cell Migration. | Bindra, GK., et al. 2022. Biomolecules. 12: PMID: 35204765
- Immunomodulatory effects of β-defensin 2 on macrophages induced immuno-upregulation and their antitumor function in breast cancer. | Agarwal, S., et al. 2022. BMC Immunol. 23: 53. PMID: 36324077
- Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling. | Rückert, T., et al. 2022. Sci Transl Med. 14: eabp9675. PMID: 36542690
- Low human beta-defensin-2 levels in the sputum of COPD patients are associated with the risk of exacerbations. | Feng, S., et al. 2023. BMC Pulm Med. 23: 106. PMID: 37003996
- Expression of Human β-defensin 2 (hBD-2) in Pichia Pastoris and Investigation of Its Binding Efficiency with ACE-2. | Çobanoğlu, Ş., et al. 2023. Protein J. 42: 399-407. PMID: 37291459
- Human α-Defensin 51-9 and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet. | Filipe Rosa, L., et al. 2023. Int J Mol Sci. 24: PMID: 37762180
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-defensin 2 Antibody (B 235-I) | sc-59494 | 50 µg/0.5 ml | $322.00 |