beta-cyano-L-Alanine CAS: 6232-19-5
MF: C4H6N2O2
MW: 114.1
A reversible inhibitor of the H2S-synthesizing enzyme cystathionine γ lyase.

β-cyano-L-Alanine (CAS 6232-19-5)

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別名: BCA
アプリケーション: β-cyano-L-Alanine is a reversible inhibitor of the H2S-synthesizing enzyme cystathionine γ lyase
CAS 番号: 6232-19-5
Molecular Weight: 114.1
Molecular Formula: C4H6N2O2
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* Refer to Certificate of Analysis for lot specific data (including water content).

β-cyano-L-Alanine (BCA) is a reversible inhibitor of the H2S-synthesizing enzyme CTH (CSE). BCA blocks H2S synthesis activity in rat liver preparations with an IC50 value of 6.5 μM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H2S synthesis. BCA at 50 mg/kg blocked both L-cysteine- and LPS-induced hyperalgesia in rats. Hydrogen sulfide (H2S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity. H2S is synthesized naturally in a range of mammalian tissues principally by the activity of two enzymes, CTH (cystathionine γ lyase CSE) and cystathionineβ synthetase (CBS).


参考文献

1 Li, L., Moore, P.K. Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air?. Trends Pharmacol Sci 29(2) 84-90 (2007). 2 Wang, R. Two's company, three's a crowd: Can H2S be the third endogenous gaseous transmitter?. FASEB J 16(13) 1792-1798 (2002). 3 Pfeffer, M., Ressler, C. b-cyanoalanine, an inhibitor of rat liver cystathionase. Biochem Pharmacol 16 2299-2308 (1967). 4 Mok, Y.P., Atan, M.S.B.M., Ping, C.Y., et al. Role of hydrogen sulphide in haemorrhagic shock in the rat: Protective effect of inhibitors of hydrogen sulphide biosynthesis. Br J Pharmacol 143 881-889 (2004). 5 Kawabata, A., Ishiki, T., Nagasawa, K., et al. Hydrogen sulfide as a novel nociceptive messenger. Pain 132 74-81 (2008).

Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml), ethanol, DMSO, DMF, and PBS (pH 7.2) (~10 mg/ml).
保存方法 :
Store at -20° C
Melting Point :
217° C
Boiling Point :
~368.1° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.50 (Predicted)
IC50 :
Blocks H2S synthesis: IC50 = 6.5 µM (rat liver preparations)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00021722
SMILES :
C(C#N)[[email protected]@H](C(=O)O)N

Download SDS (MSDS)

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