Atg4C Antibody (287CT12.2.2): sc-517311
- Atg4C Antibody (287CT12.2.2) is a mouse monoclonal IgG1 κ Atg4C antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to Atg4C of human origin
- recommended for detection of Atg4C of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Atg4C Antibody (287CT12.2.2). This work is in progress.
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Atg4C Antibody (287CT12.2.2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Atg4C protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Atg4C antibody (287CT12.2.2) is available as a non-conjugated monoclonal isotype antibody. Atg4C (287CT12.2.2) monoclonal antibody recognizes ATG4 autophagy related 4 homolog C, which plays a crucial role in autophagy process, essential for cellular homeostasis and degradation of damaged organelles and proteins. This 458 amino acid tumor suppressor protein, belonging to peptidase C54 family, is encoded by a gene located on human chromosome 1p31.3 and is conserved across various species, including chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish. Atg4C is predominantly expressed in skeletal muscle, heart, liver, and testis, where Atg4C localizes to cytoplasm. As a cysteine protease, Atg4C is responsible for cleaving C-terminal region of proteins such as MAP1LC3, GABARAPL2, or GABARAP, thereby facilitating formation of autophagosomes. Regulation of Atg4C activity is also significant, as N-ethylmaleimide can inhibit Atg4C, highlighting Atg4C′s importance in autophagy pathway and potential implications in cancer and neurodegenerative diseases.
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Atg4C Antibody (287CT12.2.2) References:
- Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. | Mariño, G., et al. 2007. J Biol Chem. 282: 18573-18583. PMID: 17442669
- Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. | Apel, A., et al. 2008. Cancer Res. 68: 1485-94. PMID: 18316613
- An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. | Fujita, N., et al. 2008. Mol Biol Cell. 19: 4651-9. PMID: 18768752
- Control of autophagy by oncogenes and tumor suppressor genes. | Maiuri, MC., et al. 2009. Cell Death Differ. 16: 87-93. PMID: 18806760
- Mutant p53 protein localized in the cytoplasm inhibits autophagy. | Morselli, E., et al. 2008. Cell Cycle. 7: 3056-61. PMID: 18818522
- Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. | Betin, VM. and Lane, JD. 2009. J Cell Sci. 122: 2554-66. PMID: 19549685
- Comprehensive analysis of expression pattern and promoter regulation of human autophagy-related genes. | Kusama, Y., et al. 2009. Apoptosis. 14: 1165-75. PMID: 19657746
- Patterns of linkage disequilibrium in different populations: implications and opportunities for lipid-associated loci identified from genome-wide association studies. | Teo, YY. and Sim, X. 2010. Curr Opin Lipidol. 21: 104-15. PMID: 20125009
- Histopathological and neurological features of Atg4b knockout mice. | Read, R., et al. 2011. Vet Pathol. 48: 486-94. PMID: 20634410
- Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux. | Wen, ZP., et al. 2019. J Exp Clin Cancer Res. 38: 298. PMID: 31291988
- Autophagy in the physiological endometrium and cancer. | Devis-Jauregui, L., et al. 2021. Autophagy. 17: 1077-1095. PMID: 32401642
- Analysis of ATG4C function in vivo. | Tamargo-Gómez, I., et al. 2023. Autophagy. 19: 2912-2933. PMID: 37459465
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Atg4C Antibody (287CT12.2.2) | sc-517311 | 100 µg/ml | $322.00 |