Atazanavir CAS: 198904-31-3
MF: C38H52N6O7
MW: 704.86
A highly potent HIV-1 protease inhibitor.

Atazanavir (CAS 198904-31-3)

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別名: BMS-232632; CGP-73547
アプリケーション: Atazanavir is a highly potent HIV-1 protease inhibitor
CAS 番号: 198904-31-3
Purity: ≥99%
Molecular Weight: 704.86
Molecular Formula: C38H52N6O7
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Atazanavir is a highly potent HIV-1 protease inhibitor. Has shown to be generally more potent than the five currently approved HIV-1 Prt inhibitors. Atazanavir (BMS-232632) inhibited the proteolytic cleavage of the viral gag precursor p55 polyprotein in a dose-dependent manner, with a EC 50 of approximately 47 nM. Also highly selective for HIV-1 Prt and exhibits cytotoxicity only at concentrations 6,500- to 23,000-fold higher than that required for anti-HIV activity. Atazanavir (BMS-232632) may be an effective HIV-1 inhibitor that may be utilized in a variety of different drug combinations.


参考文献

Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),

Physical State :
Solid
Solubility :
Soluble in methanol, ethanol (~2 mg/ml), DMSO (~16 mg/ml), DMF (~25 mg/ml), and DMF:PBS(pH 7.2) 1: 8 (~0.1 mg/ml).
保存方法 :
Store at -20° C
Melting Point :
207-209° C
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
Optical Activity :
α20/D -47°, c = 1 in ethanol
IC50 :
HIV-1 protease: EC5050 = 2.6 nM; Human immunodeficiency virus 1: IC50 = 3 nM; MT4: IC50 = 25 nM (human); Human immunodeficiency virus type 1 reverse transcriptase: IC50 = 26 nM; Human immunodeficiency virus 2: IC50 = 30 nM; OATP8: IC50 = 0.4 µM (human)
pK Values :
pKa: 11.11 (Predicted), pKb: 4.65 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
MDL Number :
MFCD08435966
SMILES :
CC(C)(C)[[email protected]@H](C(=O)N[[email protected]@H](CC1=CC=CC=C1)[[email protected]](CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)[[email protected]](C(C)(C)C)NC(=O)OC)O)NC(=O)OC

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Atazanavir (CAS 198904-31-3)  参考文献

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