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強力で選択的なセロトニン取り込み阻害薬。
Alaproclate hydrochloride (CAS 60719-83-7) 参考文献
Lindberg, U.H., et al., Inhibitors of neuronal monoamine uptake. 2. Selective inhibition of 5-hydroxytryptamine uptake by å-amino acid esters of phenethyl alcohols. J. Med. Chem. 21, 448, (1978) Orgen, S.O., et al., Alaproclate, a new selective 5-HT uptake inhibitor with therapeutic potential in depression and senile dementia. J. Neural Transm. 59, 265, (1984) Wilkinson, A., et al., Alaproclate acts as a potentreversible and noncompetitive antagonist of the NMDA receptor coupled ion flow. J. Pharmacol. Exp. Ther. 271, 1314-1319, (1994) Svensson, B.E., et al., Alaproclate effects on voltage-dependent K+ channels and NMDA receptors: studies in cultured rat hippocampal neurons and fibroblast cells transformed with Kv1.2 K+ channel cDNA. Neuropharmacology 33, 795-804, (1994)